Evidence map›Paper›PMID 32595246›Full record

ArticleActa clinica Croatica2019

THERAPEUTIC PLASMA EXCHANGE AND DOUBLE FILTRATION PLASMAPHERESIS IN SEVERE NEUROIMMUNE DISORDERS.

Corina Roman-Filip, Maria-Gabriela Catană, Alina Bereanu, Ana Lăzăroae, Felicia Gligor, Mihai Sava

Open access · diamondAbstract read
In one paragraph

Article in Acta clinica Croatica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Review
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  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Corina Roman-Filip1Lucian Blaga University, Faculty of Medicine, Sibiu, Romania; 2Department of Neurology, University Emergency County Hospital Sibiu, Sibiu, Romania; 3Department of Anesthesia, University Emergency County Hospital Sibiu, Sibiu, Romania.
Maria-Gabriela Catană1Lucian Blaga University, Faculty of Medicine, Sibiu, Romania; 2Department of Neurology, University Emergency County Hospital Sibiu, Sibiu, Romania; 3Department of Anesthesia, University Emergency County Hospital Sibiu, Sibiu, Romania.
Alina Bereanu1Lucian Blaga University, Faculty of Medicine, Sibiu, Romania; 2Department of Neurology, University Emergency County Hospital Sibiu, Sibiu, Romania; 3Department of Anesthesia, University Emergency County Hospital Sibiu, Sibiu, Romania.
Ana Lăzăroae1Lucian Blaga University, Faculty of Medicine, Sibiu, Romania; 2Department of Neurology, University Emergency County Hospital Sibiu, Sibiu, Romania; 3Department of Anesthesia, University Emergency County Hospital Sibiu, Sibiu, Romania.
Felicia Gligor1Lucian Blaga University, Faculty of Medicine, Sibiu, Romania; 2Department of Neurology, University Emergency County Hospital Sibiu, Sibiu, Romania; 3Department of Anesthesia, University Emergency County Hospital Sibiu, Sibiu, Romania.
Mihai Sava1Lucian Blaga University, Faculty of Medicine, Sibiu, Romania; 2Department of Neurology, University Emergency County Hospital Sibiu, Sibiu, Romania; 3Department of Anesthesia, University Emergency County Hospital Sibiu, Sibiu, Romania.
Lucian Blaga University of Sibiu · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique, which removes large molecular weight particles such as autoantibodies from plasma. TPE is accepted by the American Society for Apheresis as first line treatment for some severe neuroimmune disorders. Double filtration plasmapheresis (DFPP) is a newer technique in which plasma is not entirely removed, only the antibodies, using special filters. High-dose intravenous immunoglobulins are an alternative treatment for these patients but are much more expensive. We reviewed medical records of 20 patients with severe neurological diseases requiring TPE or DFPP. We analyzed the indications, complications and efficacy of these procedures. After completing the procedures, neurological improvement was recorded in 80% of the patients, 5% had no improvement, and the mortality was 15%. The rate of neurological improvement was similar to other studies. None of the patients presented catheter related complications. Systemic complications were mild, transient and completely reversible.

Indexed as

AdolescentAdultAgedAged, 80 and overHumansImmune System DiseasesImmunoglobulins, IntravenousMaleMiddle AgedNervous System DiseasesPlasma ExchangePlasmapheresisYoung AdultImmunoglobulins, IntravenousAutoimmune diseases of the nervous systemImmunoglobulins, intravenousPlasma exchangePlasmapheresis

Identifiers

PMID32595246
PMCPMC7314295
OpenAlexW3010783588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.