ArticleJournal of atherosclerosis and thrombosis2021
Intracranial Calcification is Predictive for Hemorrhagic Transformation and Prognosis After Intravenous Thrombolysis in Non-Cardioembolic Stroke Patients.
Article in Journal of atherosclerosis and thrombosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Intracranial Artery Calcification Relates to Brain Damage and Clinical Outcomes in Patients Receiving Intravenous Thrombolysis.Journal of atherosclerosis and thrombosis · 2026Article
- Intracranial and extracranial artery stenosis and clinical outcome of acute ischemic stroke patients receiving intravenous thrombolysis.Frontiers in neurology · 2025Article
- Machine learning models integrating intracranial artery calcification to predict outcomes of mechanical thrombectomy.Frontiers in neurology · 2025Article
- Predictive Value of Epicardial Adipose Tissue for Hemorrhagic Transformation and Functional Outcomes in Acute Ischemic Stroke Patients Undergoing Intravenous Thrombolysis Therapy.Journal of inflammation research · 2024Article
- A weakly supervised deep learning model integrating noncontrasted computed tomography images and clinical factors facilitates haemorrhagic transformation prediction after intravenous thrombolysis in acute ischaemic stroke patients.Biomedical engineering online · 2023Article
- Prediction factors and clinical significance of different types of hemorrhagic transformation after intravenous thrombolysis.European journal of medical research · 2023Article
- Hemorrhagic Transformation of Ischemic Strokes.International journal of molecular sciences · 2023Review
- Symptomatic Intracranial Hemorrhage after Ischemic Stroke Treated with Bridging Revascularization Therapy.Life (Basel, Switzerland) · 2023Article
- The correlation between intracranial arterial calcification and the outcome of reperfusion therapy.Annals of clinical and translational neurology · 2023Article
- Carotid Siphon Calcification Predicts the Symptomatic Progression in Branch Artery Disease With Intracranial Artery Stenosis-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Arterial Calcification and Its Association With Stroke: Implication of Risk, Prognosis, Treatment Response, and Prevention.Frontiers in cellular neuroscience · 2022Review
- Intracranial Arterial Calcifications: Potential Biomarkers of Stroke Risk and Outcome.Frontiers in neurology · 2022Review
- Prognostic values of serum alkaline phosphatase and globulin levels in patients undergoing intravenous thrombolysis.Frontiers in molecular neuroscience · 2022Article
- Histology-Verified Intracranial Artery Calcification and Its Clinical Relevance With Cerebrovascular Disease.Frontiers in neurology · 2021Review
- Intracranial Bleeding After Reperfusion Therapy in Acute Ischemic Stroke.Frontiers in neurology · 2020Review
- Comparison of symptomatic vertebrobasilar plaques between patients with and without Diabetes Mellitus using computed tomographic angiography and vessel wall magnetic resonance imaging.Diabetes & vascular disease researchArticle
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimHemorrhagic transformation is the major complication of intravenous thrombolysis. Calcification is used widely as an imaging indicator of atherosclerotic burden and cerebrovascular function. The relationship between intracranial calcification and hemorrhagic transformation has not been explored fully. We aimed to identify and quantify calcification in the main cerebral vessels to investigate the correlations between quantitative calcification parameters, hemorrhagic transformation, and prognosis.
methodsAcute, non-cardiogenic, ischemic stroke patients with anterior circulation who received intravenous thrombolysis therapy in the First Hospital of Jilin University were retrospectively and consecutively included. All included patients underwent a baseline CT before intravenous thrombolysis and a follow-up CT at 24 hours. A third-party software, ITK-SNAP, was used to segment and measure the calcification volume. A vascular non-bone component with a CT value ＞130 HU was considered calcified. Hemorrhagic transformation was determined based on the ECASS II classification criteria.
resultsThe study included 242 patients, 214 of whom were identified as having calcification. Thirty-one patients developed hemorrhagic transformation. The calcification volume on the lesion side (0.1ml) was associated with hemorrhagic transformation (p=0.004, OR=1.504, 95% CI: 1.140-1.985). Ninety-six patients had poor prognoses. The poor prognosis group had more calcified vessels than the good prognosis group (p=0.014, OR=1.477, 95% CI: 1.083-2.015).
conclusionsThe arterial calcification volume on the lesion side is associated with hemorrhagic transformation after thrombolysis. The higher the number of calcified vessels, the greater the risk of poor prognosis.
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