Evidence map›Paper›PMID 32595186›Full record

ReviewJournal of atherosclerosis and thrombosis2020

New Horizons of Arterial Stiffness Developed Using Cardio-Ankle Vascular Index (CAVI).

Atsuhito Saiki, Masahiro Ohira, Takashi Yamaguchi, Daiji Nagayama, Naomi Shimizu, Kohji Shirai, Ichiro Tatsuno

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of atherosclerosis and thrombosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Changes in segmental arterial stiffness and volume dynamics across the arterial tree during noradrenaline administration in rabbits.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  6. Article
  7. Review
  8. Cardio-Ankle Vascular Index and left ventricular mass as markers of nocturnal blood pressure fall in the general population.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
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  15. Review
  16. Article
  17. Article
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  19. Review
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Atsuhito SaikiCenter of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center.
Masahiro OhiraCenter of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center.
Takashi YamaguchiCenter of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center.
Daiji NagayamaNagayama Clinic.
Naomi ShimizuCenter of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center.
Kohji ShiraiDepartment of Internal Medicine, Mihama Hospital.
Ichiro TatsunoCenter of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center.
Toho University · JPToho University Medical Center Sakura Hospital · JPTomitahama Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arterial stiffness is recognized mainly as an indicator of arteriosclerosis and a predictor of cardiovascular events. Cardio-ankle vascular index (CAVI), which reflects arterial stiffness from the origin of the aorta to the ankle, was developed in 2004. An important feature of this index is the independency from blood pressure at the time of measurement. A large volume of clinical evidence obtained using CAVI has been reported. CAVI is high in patients with various atherosclerotic diseases including coronary artery disease and chronic kidney disease. Most coronary risk factors increase CAVI and their improvement reduces CAVI. Many prospective studies have investigated the association between CAVI and future cardiovascular disease (CVD), and proposed CAVI of 9 as the optimal cut-off value for predicting CVD. Research also shows that CAVI reflects afterload and left ventricular diastolic dysfunction in patients with heart failure. Furthermore, relatively acute changes in CAVI are observed under various pathophysiological conditions including mental stress, septic shock and congestive heart failure, and in pharmacological studies. CAVI seems to reflect not only structural stiffness but also functional stiffness involved in acute vascular functions. In 2016, Spronck and colleagues proposed a variant index CAVI

Indexed as

Vascular StiffnessAnimalsAtherosclerosisCardio Ankle Vascular IndexCardiovascular DiseasesHumansArterial stiffnessCardio-ankle vascular indexCardiovascular diseaseHeart failureStiffness parameter β

Identifiers

PMID32595186
PMCPMC7458785
OpenAlexW3037283771

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.