Evidence map›Paper›PMID 32595159›Full record

ArticleBMJ open2020

Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol.

Vincent Issac Lau, Deborah J Cook, Robert Fowler, Bram Rochwerg, Jennie Johnstone, François Lauzier, John C Marshall, John Basmaji, Diane Heels-Ansdell, Lehana Thabane and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01782755 (Probiotics), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01782755 phase2completednot on this map

Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT): A Feasibility Clinical Trial

TypeinterventionalSponsorMcMaster UniversityRan2013 to 2015Enrolled150ConditionsVentilator Associated Pneumonia (VAP), Other Infections, Antibiotic-Associated Diarrhea, C-DifficileArmsL. rhamnosus GG - Probiotic, Placebo - Microcrystalline Cellulose
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Vincent Issac LauDepartment of Critical Care, University of Alberta Faculty of Medicine and Dentistry, Edmonton, Alberta, Canada vinceissaclau@gmail.com.ORCID 0000-0002-9939-7348
Deborah J CookDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Robert FowlerSunnybrook Health Sciences Institute, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Bram RochwergDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-8293-7061
Jennie JohnstonePublic Health Ontario, University of Toronto Dalla Lana School of Public Health, Toronto, Ontario, Canada.
François LauzierPopulation Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), Centre de Recherche du CHU de Québec-Université Laval, Quebec, Quebec, Canada.
John C MarshallDepartment of Surgery, University of Toronto, Toronto, Ontario, Canada.
John BasmajiDepartment of Medicine, Division of Critical Care, Western University, London, Ontario, Canada.
Diane Heels-AnsdellDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Lehana ThabaneDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Feng XieDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
PROSPECT Collaborators
Impact · CAUniversity of Toronto · CASunnybrook Health Science Centre · CAUniversité Laval · CAUniversity of Alberta · CAWestern University · CA

Funding

CIHR
6 · The paper itself

Abstract

introductionVentilator-associated pneumonia (VAP) is a common healthcare-associated infection in the intensive care unit (ICU). Probiotics are defined as live microorganisms that may confer health benefits when ingested. Prior randomised trials suggest that probiotics may prevent infections such as VAP and METHODS AND ANALYSIS: The objective of E-PROSPECT is to determine the incremental cost-effectiveness of ETHICS AND DISSEMINATION: Study approval for E-PROSPECT was granted by the Hamilton Integrated Research Ethics Board of McMaster University on 29 July 2019. Informed consent was obtained from the patient or substitute decision-maker in PROSPECT. The findings of this study will be published in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT01782755; Pre-results.

Indexed as

Cost-Benefit AnalysisCritical IllnessHumansIntensive Care UnitsLacticaseibacillus rhamnosusMulticenter Studies as TopicPneumonia, Ventilator-AssociatedProbioticsRandomized Controlled Trials as TopicResearch DesignTracheaadult intensive & critical carehealth economicsinfectious diseasesmicrobiologypreventive medicinestatistics & research methods

Identifiers

PMID32595159
PMCPMC7322334
OpenAlexW3037668313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.