ArticleJournal of diabetes investigation2021
Relationships between time in range, glycemic variability including hypoglycemia and types of diabetes therapy in Japanese patients with type 2 diabetes mellitus: Hyogo Diabetes Hypoglycemia Cognition Complications study.
Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Correlation between time on target and glycated hemoglobin in people with diabetes mellitus: systematic review.Revista latino-americana de enfermagem · 2023Pooled it
- Time in range, as measured by continuous glucose monitor, as a predictor of microvascular complications in type 2 diabetes: a systematic review.BMJ open diabetes research & care · 2022Pooled it
- Enlarged glycemic variability in sulfonylurea-treated well-controlled type 2 diabetics identified using continuous glucose monitoring.Scientific reports · 2021Trial
- Time in Range and Adverse Outcomes in Type 2 Diabetes: A Quantitative Synthesis.Journal of clinical medicine · 2026Review
- Linking glucose swings and mental health to cardiovascular outcomes and mortality in general practice.Scientific reports · 2025Article
- Continuous glucose monitoring-derived time in range is associated with changes in cognitive function test scores in Japanese patients with type 2 diabetes mellitus.Diabetes, obesity & metabolism · 2025Article
- Developing CGMap: Characterizing Continuous Glucose Monitoring Data in Patients with Type 2 Diabetes.Biomedicines · 2025Article
- Impact of Continuous Glucose Monitoring and its Glucometrics in Clinical Practice in Spain and Future Perspectives: A Narrative Review.Advances in therapy · 2024Review
- Association between continuous glucose monitoring-derived glycemic control indices and urinary biomarkers of diabetic kidney disease: Hyogo Diabetes Hypoglycemia Cognition Complications study.Acta diabetologica · 2024Article
- Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus.BMJ open diabetes research & care · 2024Article
- Use of Continuous Glucose Monitoring and Glucagon-Like Peptide 1 Receptor Agonist Therapy to Achieve Individualized Treatment Goals in Insulin-Treated People With Type 2 Diabetes: A Case Series and Expert Opinion.Clinical diabetes : a publication of the American Diabetes Association · 2024Article
- Chemical characterization, antioxidant and antidiabetic activities of a novel polyherbal formulation comprising ofHeliyon · 2023Article
- What is Glycaemic Variability and which Pharmacological Treatment Options are Effective? A Narrative Review.TouchREVIEWS in endocrinology · 2023Review
- Differential correlation between time in range and eGFR or albuminuria in type 2 diabetes.Diabetology & metabolic syndrome · 2023Article
- Association between low-carbohydrate diets and continuous glucose monitoring-derived time in ranges.Journal of diabetes investigation · 2023Article
- Time trends (2012-2020) in glycated hemoglobin and adherence to the glycemic targets recommended for elderly patients by the Japan Diabetes Society/Japan Geriatrics Society Joint Committee among memory clinic patients with diabetes mellitus.Journal of diabetes investigation · 2022Article
- Time in range assessed by capillary blood glucose in relation to insulin sensitivity and β-cell function in patients with type 2 diabetes mellitus: A cross-sectional study in China.Journal of diabetes investigation · 2022Article
- Association Between HbA1c Levels and Diabetic Peripheral Neuropathy: A Case-Control Study of Patients with Type 2 Diabetes Using Claims Data.Drugs - real world outcomes · 2022Article
- Comparison of glucose time in range and area under curve in range in relation to risk of diabetic retinopathy in type 2 diabetes patients.Journal of diabetes investigation · 2022Article
- Complications of Diabetes and Metrics of Glycemic Management Derived From Continuous Glucose Monitoring.The Journal of clinical endocrinology and metabolism · 2022Review
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 1 country.
Funding
Abstract
AIMS/
introductionContinuous glucose monitoring (CGM) metrics, such as times in range (TIR) and time below range, have been shown to be useful as clinical targets that complement glycated hemoglobin (HbA1c) for patients with type 2 diabetes mellitus. We investigated the relationships between TIR, glycemic variability and patient characteristics in patients with type 2 diabetes mellitus. MATERIALS AND
methodsWe carried out continuous glucose monitoring in 281 outpatients with type 2 diabetes mellitus who participated in a multicenter cohort (Hyogo Diabetes Hypoglycemia Cognition Complications) study.
resultsThe results are shown as the median (interquartile range). The age, disease duration and HbA1c were 68 years (62-71 years), 13 years (7-23 years) and 6.9% (6.5-7.5%), respectively. TIR and standard deviation obtained by continuous glucose monitoring worsened significantly with increasing disease duration. Multiple regression analyses showed that disease duration (standard partial regression coefficient, β = -0.160, P = 0.003), diabetic peripheral neuropathy (β = -0.106, P = 0.033) and urinary albumin excretion (β = -0.100, P = 0.043) were useful explanatory factors for TIR. In contrast, HbA1c (β = -0.398, P < 0.001) and the use of antidiabetic drugs potentially associated with severe hypoglycemia (β = 0.180, P = 0.028), such as sulfonylureas, glinides and insulin, were useful explanatory factors for time below range in the elderly patients with type 2 diabetes mellitus.
conclusionsThe results of this study suggest that disease duration and diabetic complications are associated with TIR deterioration. In addition, low HbA1c levels and the use of antidiabetic drugs potentially associated with severe hypoglycemia might worsen the time below range in the elderly.
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