ArticleJournal of neuroscience research2021
Lesion network mapping demonstrates that mind-wandering is associated with the default mode network.
Article in Journal of neuroscience research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- The Relative Accuracy of Different Methods for Measuring Mind Wandering Subtypes: A Systematic Review.Brain and behavior · 2025Pooled it
- Activation network mapping for integration of heterogeneous fMRI findings.Nature human behaviour · 2022Pooled it
- Mindfulness meditation increases default mode, salience, and central executive network connectivity.Scientific reports · 2022Trial
- Mapping the Relationship Between Core Executive Functions and Mind Wandering in Children and Adolescents: A Systematic Review.Journal of Intelligence · 2026Review
- Reduced mind-wandering and fewer depressive symptoms associated with damage to the medial prefrontal cortex and default mode network.Neuropsychologia · 2025Article
- Creativity and its link to epilepsy.Epilepsia open · 2024Review
- Taking time to compose thoughts with prefrontal schemata.Experimental brain research · 2024Article
- The language network as a natural kind within the broader landscape of the human brain.Nature reviews. Neuroscience · 2024Review
- Review
- Large-scale lesion symptom mapping of depression identifies brain regions for risk and resilience.Brain : a journal of neurology · 2023Article
- Functional and structural lesion network mapping in neurological and psychiatric disorders: a systematic review.Frontiers in neurology · 2023Article
- Sleep to Internalizing Pathway in Young Adolescents (SIPYA): A proposed neurodevelopmental model.Neuroscience and biobehavioral reviews · 2022Review
- Mind-wandering: mechanistic insights from lesion, tDCS, and iEEG.Trends in cognitive sciences · 2022Review
- Predicting lapses of attention with sleep-like slow waves.Nature communications · 2021Article
- Lesion network mapping predicts post-stroke behavioural deficits and improves localization.Brain : a journal of neurology · 2021Article
- Prediction of stimulus-independent and task-unrelated thought from functional brain networks.Nature communications · 2021Article
- Lesion network mapping: where do we go from here?Brain : a journal of neurology · 2021Article
- Default Mode Network Resting State Connectivity Derived From Task-Based fMRI: A Validation Study in People With Epilepsy.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Functional neuroimaging research has consistently associated brain structures within the default mode network (DMN) and frontoparietal network (FPN) with mind-wandering. Targeted lesion research has documented impairments in mind-wandering after damage to the medial prefrontal cortex (mPFC) and hippocampal regions associated with the DMN. However, no lesion studies to date have applied lesion network mapping to identify common networks associated with deficits in mind-wandering. In lesion network mapping, resting-state functional connectivity data from healthy participants are used to infer which brain regions are functionally connected to each lesion location from a sample with brain injury. In the current study, we conducted a lesion network mapping analysis to test the hypothesis that lesions affecting the DMN and FPN would be associated with diminished mind-wandering. We assessed mind-wandering frequency on the Imaginal Processes Inventory (IPI) in participants with brain injury (n = 29) and healthy comparison participants without brain injury (n = 19). Lesion network mapping analyses showed the strongest association of reduced mind-wandering with the left inferior parietal lobule within the DMN. In addition, traditional lesion symptom mapping results revealed that reduced mind-wandering was associated with lesions of the dorsal, ventral, and anterior sectors of mPFC, parietal lobule, and inferior frontal gyrus in the DMN (p < 0.05 uncorrected). These findings provide novel lesion support for the role of the DMN in mind-wandering and contribute to a burgeoning literature on the neural correlates of spontaneous cognition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.