Evidence map›Paper›PMID 32594462›Full record

SynthesisDigestive diseases and sciences2021

Various Modalities Accurate in Diagnosing a Disrupted or Disconnected Pancreatic Duct in Acute Pancreatitis: A Systematic Review.

Hester C Timmerhuis, Sven M van Dijk, Robert C Verdonk, Thomas L Bollen, Marco J Bruno, Paul Fockens, Jeanin E van Hooft, Rogier P Voermans, Marc G Besselink, Hjalmar C van Santvoort and 1 more

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Hester C TimmerhuisDepartment of Research and Development, St. Antonius Hospital, PO 2500, 3430 EM, Nieuwegein, The Netherlands.ORCID 0000-0001-5714-4951
Sven M van DijkDepartment of Research and Development, St. Antonius Hospital, PO 2500, 3430 EM, Nieuwegein, The Netherlands.
Robert C VerdonkDepartment of Gastroenterology and Hepatology, St. Antonius Hospital, PO 2500, 3430 EM, Nieuwegein, The Netherlands.
Thomas L BollenDepartment of Radiology, St. Antonius Hospital, PO 2500, 3430 EM, Nieuwegein, The Netherlands.
Marco J BrunoDepartment of Gastroenterology, Erasmus MC University Medical Center, PO 2040, 3000 CA, Rotterdam, The Netherlands.
Paul FockensDepartment of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, PO 22660, 1100 DD, Amsterdam, The Netherlands.
Jeanin E van HooftDepartment of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, PO 22660, 1100 DD, Amsterdam, The Netherlands.
Rogier P VoermansDepartment of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, PO 22660, 1100 DD, Amsterdam, The Netherlands.
Marc G BesselinkDepartment of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, PO 22660, 1100 DD, Amsterdam, The Netherlands.
Hjalmar C van SantvoortDepartment of Surgery, St. Antonius Hospital, PO 2500, 3430 EM, Nieuwegein, The Netherlands. h.vansantvoort@umcutrecht.nl.
Dutch Pancreatitis Study Group
Amsterdam University Medical Centers · NLSt. Antonius Ziekenhuis · NLErasmus MC · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere pancreatitis may result in a disrupted pancreatic duct, which is associated with a complicated clinical course. Diagnosis of a disrupted pancreatic duct is not standardized in clinical practice or international guidelines. We performed a systematic review of the literature on imaging modalities for diagnosing a disrupted pancreatic duct in patients with acute pancreatitis.

methodsA systematic search was performed in PubMed, Embase and Cochrane library databases to identify all studies evaluating diagnostic modalities for the diagnosis of a disrupted pancreatic duct in acute pancreatitis. All data regarding diagnostic accuracy were extracted.

resultsWe included 8 studies, evaluating five different diagnostic modalities in 142 patients with severe acute pancreatitis. Study quality was assessed, with proportionally divided high and low risk of bias and low applicability concerns in 75% of the studies. A sensitivity of 100% was reported for endoscopic ultrasound and endoscopic retrograde cholangiopancreatography. The sensitivity of magnetic resonance cholangiopancreatography with or without secretin was 83%. A sensitivity of 92% was demonstrated for a combined cohort of secretin-magnetic resonance cholangiopancreatography and magnetic resonance cholangiopancreatography. A sensitivity of 100% and specificity of 50% was found for amylase measurements in drain fluid compared with ERCP.

conclusionsThis review suggests that various diagnostic modalities are accurate in diagnosing a disrupted pancreatic duct in patients with acute pancreatitis. Amylase measurement in drain fluid should be standardized. Given the invasive nature of other modalities, secretin-magnetic resonance cholangiopancreatography or magnetic resonance cholangiopancreatography would be recommended as first diagnostic modality. Further prospective studies, however, are needed.

Indexed as

Cholangiopancreatography, Endoscopic RetrogradeCholangiopancreatography, Magnetic ResonanceEndosonographyAmylasesBiomarkersClinical Enzyme TestsHumansPancreatic DuctsPancreatitisPredictive Value of TestsReproducibility of ResultsSecretinSeverity of Illness IndexAmylasesBiomarkersSecretinAcute necrotizing pancreatitisDisconnected pancreatic ductDisrupted pancreatic ductPancreatic fistula

Identifiers

PMID32594462
PMCPMC8053185
OpenAlexW3037497196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.