ArticleClinical journal of gastroenterology2020
Two independent families with strongly suspected hereditary diffuse gastric cancer based on the probands' endoscopic findings.
Article in Clinical journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Hereditary diffuse gastric cancer with carcinogenesis from ectopic gastric mucosa in the duodenum.Clinical journal of gastroenterology · 2026Article
- Article
- Hereditary Diffuse Gastric Cancer Treated by Prophylactic Total Gastrectomy.Internal medicine (Tokyo, Japan) · 2024Article
- Invasive stratified mucin-producing carcinoma of the colorectum: expanding the morphologic spectrum of large bowel cancer.Diagnostic pathology · 2023Article
- Lifestyles, genetics, and future perspectives on gastric cancer in east Asian populations.Journal of human genetics · 2021Review
- Case series of three patients with hereditary diffuse gastric cancer in a single family: Three case reports and review of literature.World journal of gastroenterology · 2020Review
- Hereditary Diffuse Gastric Cancer With Poorly Differentiated Gallbladder Adenocarcinoma: A Case Report Suggesting Carcinogenesis in the Stomach and Gallbladder Caused by a Pathogenic Germline Variant inIn vivo (Athens, Greece)Article
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10 authors at 6 institutions in 1 country.
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Abstract
Hereditary diffuse gastric cancer (HDGC) is the most famous of hereditary gastric cancer syndromes with an autosomal dominant inheritance pattern, and its diagnosis can be made by identifying a pathogenic germline variant in CDH1. We report two independent families that were strongly suspected of having HDGC based on endoscopic findings (multiple tiny, pale areas) obtained in the probands; the probands were pathologically diagnosed as having signet ring cell carcinoma (SRCC) and were genetically confirmed to have a pathogenic CDH1 germline variant. Although the updated International Gastric Cancer Linkage Consortium (IGCLC)'s clinical guidelines for HDGC (2015) state that screening/surveillance endoscopy should be performed (Cambridge protocol), the endoscopic findings obtained in the two presently reported families suggest that pale areas should be suspected as indicating the presence of SRCCs, and biopsies should be performed in addition to obtaining a precise family history in cases suspected of having HDGC.
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