Evidence map›Paper›PMID 32594343›Full record

ArticleMolecular biology reports2020

Mutations in the Reelin pathway are associated with abnormal expression of microglial IgG FC receptors in the cerebellar cortex.

Maryam Rahimi-Balaei, Xiaodan Jiao, Azadeh Dalvand, Shahin Shabanipour, Seung H Chung, Shayan Amiri, Jimig Kong, Hassan Marzban

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Very low-density lipoprotein and the human health.World journal of experimental medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Maryam Rahimi-BalaeiDepartment of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Xiaodan JiaoDepartment of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Azadeh DalvandDepartment of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Shahin ShabanipourDepartment of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Seung H ChungDepartment of Oral Biology, University of Illinois at Chicago, Chicago, IL, USA.
Shayan AmiriDepartment of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Jimig KongDepartment of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Hassan MarzbanDepartment of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. Hassan.marzban@umanitoba.ca.ORCID http://orcid.org/0000-0001-6885-2590
University of Manitoba · CAChildren's Hospital Research Institute of Manitoba · CAUniversity of Illinois Chicago · US

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2018-06040
6 · The paper itself

Abstract

Microglia are the immune cells of the central nervous system involved in a variety of developmental processes, such as regulation of cell death and survival, spatial patterning, and contribute to the development of Purkinje cells (PCs) during migration. Microglia express immunoglobulin G Fc receptors (FcgRs). In this report, we describe microglial FcgR expression and its relation to abnormal PC migration in the cerebellum during development. To detect microglial FcgR, the direct anti-IgG (secondary antisera) and high concentrations of Triton X-100 were applied as a method for labeling microglial cells without the use of any specific primary antiserum. By using Acp2

Indexed as

Acid PhosphataseAnimalsApolipoproteins ECell Adhesion Molecules, NeuronalCell MovementExtracellular Matrix ProteinsMiceMice, Inbred C57BLMicrogliaMutationNerve Tissue ProteinsPurkinje CellsReceptors, FcReelin ProteinSerine EndopeptidasesSignal TransductionAcid PhosphataseAcp2 protein, mouseApoe protein, mouseApolipoproteins ECell Adhesion Molecules, NeuronalDab1 protein, mouseExtracellular Matrix ProteinsNerve Tissue ProteinsReceptors, FcReelin ProteinRELN protein, humanReln protein, mouseSerine EndopeptidasesCerebellumIgG FC receptorsMiceMicrogliaPurkinje cellsReelin

Identifiers

PMID32594343
OpenAlexW3037052872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.