Evidence map›Paper›PMID 32594304›Full record

ArticleIrish journal of medical science2021

Intense remodeling of extracellular matrix within the varicose vein: the role of gelatinases and vascular endothelial growth factor.

Anna Horecka, Anna Hordyjewska, Jadwiga Biernacka, Wojciech Dąbrowski, Tomasz Zubilewicz, Agnieszka Malec, Irena Musik, Jacek Kurzepa

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Irish journal of medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Combined Effects of Diosmin, Hesperidin,International journal of molecular sciences · 2025
    Article
  4. Article
  5. Article
  6. Molecular Determinants of Chronic Venous Disease: A Comprehensive Review.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anna HoreckaDepartment of Medical Chemistry, Medical University of Lublin, Chodźki 4A,, 20-093, Lublin, Poland. anna.horecka@umlub.pl.ORCID https://orcid.org/0000-0002-8694-8542
Anna HordyjewskaDepartment of Medical Chemistry, Medical University of Lublin, Chodźki 4A,, 20-093, Lublin, Poland.
Jadwiga BiernackaI Clinic of Anaesthesiology and Intensive Therapy with Clinical Paediatric Department, Medical University of Lublin, Jaczewskiego 8, 20-090, Lublin, Poland.
Wojciech DąbrowskiI Clinic of Anaesthesiology and Intensive Therapy with Clinical Paediatric Department, Medical University of Lublin, Jaczewskiego 8, 20-090, Lublin, Poland.
Tomasz ZubilewiczDepartment of Vascular Surgery and Angiology, Medical University of Lublin, Staszica 17, 20-081, Lublin, Poland.
Agnieszka MalecDepartment of Obstetrics and Pathology of Pregnancy, Staszica 16, 20-081, Lublin, Poland.
Irena MusikDepartment of Medical Chemistry, Medical University of Lublin, Chodźki 4A,, 20-093, Lublin, Poland.
Jacek KurzepaDepartment of Medical Chemistry, Medical University of Lublin, Chodźki 4A,, 20-093, Lublin, Poland.
Medical University of Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased blood pressure in the varicose veins (VV) can contribute to the overexpression of matrix metalloproteinases (MMPs), affecting the endothelium, smooth muscle, and extracellular matrix of the vein wall. Gelatinases (MMP-2 and MMP-9), hypoxia, and inflammation occurring in the VV wall contribute to the increased expression of vascular endothelial growth factor (VEGF).

aimsOur objective was to analyze the concentration of gelatinases and VEGF in the great saphenous VV wall and plasma of patients.

methodsIn total, 65 patients (2nd degree according to clinical state classification, etiology, anatomy, and pathophysiology-CEAP classification) aged 22 to 70 were enrolled. Control veins (n = 10) were collected from the patients who underwent coronary artery bypass graft surgery. Control plasma (n = 20) was obtained from healthy individuals. Gelatinases and VEGF levels were measured with the usage of ELISA method.

resultsA significant increase in MMP-9 (11.2 vs. 9.98 ng/mg of protein) and VEGF (41.06 vs. 26 ng/g of protein) concentration in VV wall compared with control veins was observed. A positive correlation between VEGF versus MMP-2 (p = 0.03, r = 0.27) was found in the VV wall. However, no correlation was found between the concentration of VEGF and MMP-9 (p = 0.4, r = 0.11) in the VV wall. In addition, no statistical differences between MMP-9, MMP-2, and VEGF levels in plasma of VV patients compared with controls were noticed.

conclusionsThe results of the present study confirm that VV's patients have altered expression of MMPs and VEGF. Overexpression of MMP-9 and VEGF in the VV wall may contribute to the spreading of inflammatory process and suggests the intense remodeling of extracellular tissue within the VV wall.

Indexed as

AdultAgedExtracellular MatrixFemaleGelatinasesHumansMaleMiddle AgedVaricose VeinsVascular Endothelial Growth Factor AYoung AdultGelatinasesVascular Endothelial Growth Factor AGelatinasesVaricose veinsVascular endothelial growth factor

Identifiers

PMID32594304
PMCPMC7846537
OpenAlexW3037197468

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.