ArticleJournal of neural transmission (Vienna, Austria : 1996)2020
Supplementary motor area functional connectivity in "drug-naïve" Parkinson's disease patients with fatigue.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Functional Connectivity Alterations of the Central Autonomic Network in Multiple Sclerosis: Links to Fatigue and Aerobic Training Effects.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Predictive processes linking sense of agency and fatigue: a novel allostatic framework.Frontiers in psychology · 2026Article
- Mapping the neural and molecular basis underlying fatigue in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Molecular-Informed Network Analysis Unveils Fatigue-Related Functional Connectivity in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Observational
- Pain and fatigue in Parkinson's disease: advances in diagnosis and management.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- The Role of MAO-B Inhibitors in Fatigue in Parkinson's Disease: A Narrative Review.Journal of clinical medicine · 2025Review
- Analysis of cognitive dysfunction in Parkinson's disease using voxel based morphometry and radiomics.Cognitive processing · 2024Article
- Understanding the role of cerebellum in early Parkinson's disease: a structural and functional MRI study.NPJ Parkinson's disease · 2024Article
- Aberrant voxel-based degree centrality and functional connectivity in Parkinson's disease patients with fatigue.CNS neuroscience & therapeutics · 2023Article
- Predicting the fatigue in Parkinson's disease using inertial sensor gait data and clinical characteristics.Frontiers in neurology · 2023Article
- Impaired Interhemispheric Synchrony in Parkinson's Disease with Fatigue.Journal of personalized medicine · 2022Article
- The Supplementary Motor Complex in Parkinson's Disease.Journal of movement disorders · 2022Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatigue is a common and disabling nonmotor manifestation in patients with Parkinson's disease (PD), and the supplementary motor area (SMA) has been implicated in its pathophysiology. SMA is usually divided in its rostro-caudal axis, with the rostral (pre-) SMA playing a major role in motor planning, and the caudal (proper) SMA related to movement execution. To investigate brain functional connectivity of SMA subregions in de novo, drug-naïve PD patients affected by fatigue, 17 patients with fatigue, 18 without fatigue, and 16 matched healthy controls were recruited. All the participants were not depressed and did not suffer from daytime sleepiness. Parkinson Fatigue Scale (PFS) was used for fatigue screening (cut-off > 3.3 points) and severity rating. Seed-based resting-state functional MRI was used to compare the functional connectivity from bilateral SMA subregions to the whole brain. Voxel-based morphometry analysis was employed to test whether functional connectivity results were related to brain structural differences. PD-related fatigue was associated with an increased connectivity between the left pre-SMA and the left postcentral gyrus as well as a decreased connectivity between the left SMA proper and the left middle frontal gyrus (p
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