Evidence map›Paper›PMID 32594193›Full record

ArticleExperimental brain research2020

Dopamine boosts intention and action awareness in Parkinson's disease.

Steven Di Costa, Ewgenia Barow, Ute Hidding, Tina Mainka, Monika Pötter-Nerger, Carsten Buhmann, Christian K E Moll, Patrick Haggard, Christos Ganos

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Impulsivity traits and awareness of motor intention in Parkinson's disease: a proof-of-concept study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Steven Di CostaInstitute of Cognitive Neuroscience, University College London (UCL), London, UK.
Ewgenia BarowDepartment of Neurology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Ute HiddingDepartment of Neurology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Tina MainkaDepartment of Neurology, Charité University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Monika Pötter-NergerDepartment of Neurology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Carsten BuhmannDepartment of Neurology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Christian K E MollDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Patrick HaggardInstitute of Cognitive Neuroscience, University College London (UCL), London, UK.
Christos GanosDepartment of Neurology, Charité University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany. cganos@gmail.com.
Universität Hamburg · DECharité - Universitätsmedizin Berlin · DEUniversity College London · GBUniversity Medical Center Hamburg-Eppendorf · DE

Funding

1169/100 1169/100
6 · The paper itself

Abstract

Dopaminergic deficiency in Parkinson's disease (PD) has been associated with underactivation of the supplementary motor area and a reduction of voluntary actions. In these patients, awareness of intention to act has been shown to be delayed. However, delayed awareness of intention to act has also been shown in patients with hyperdopaminergic states and an excess of unwilled movements, as in Tourette's, and in patients with functional movement disorders. Hence, the role of dopamine in the awareness of intention and action remains unclear. 36 PD patients were tested ON and OFF dopaminergic medication and compared with 35 healthy age-matched controls. In addition, 17 PD patients with subthalamic deep brain stimulation (DBS) were tested ON medication and ON and OFF stimulation. Participants judged either the moment a self-generated action was performed, or the moment the urge to perform the action was felt, using the "Libet method". Temporal judgments of intention and action awareness were comparable between unmedicated PD patients and controls. Dopaminergic medication boosted anticipatory awareness of both intentions and actions in PD patients, relative to an unmedicated condition. The difference between ON/OFF DBS was not statistically reliable. Functional improvement of motor ability in PD through dopaminergic supplementation leads to earlier awareness of both intention, and of voluntary action.

Indexed as

Deep Brain StimulationParkinson DiseaseDopamineDopamine AgentsHumansIntentionMovementDopamineDopamine AgentsAction awarenessDopamineIntention awarenessLibetParkinson’s disease

Identifiers

PMID32594193
PMCPMC7438368
OpenAlexW3037904825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.