ArticleEuropean heart journal. Cardiovascular Imaging2020
Sex-specific relationships between patterns of ventricular remodelling and clinical outcomes.
Article in European heart journal. Cardiovascular Imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Machine Learning in Left Ventricular Hypertrophy Detection: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Heart Failure with Preserved Ejection Fraction in Women: Sex-Specific Insights Across the Continuum from Diagnosis to Outcomes.Current cardiology reports · 2026Review
- The Impact of Frailty on Left Ventricle Mass and Geometry in Elderly Patients with Normal Ejection Fraction: A STROBE-Compliant Cross-Sectional Study.Journal of cardiovascular development and disease · 2026Article
- Sex-specific structural and functional cardiac remodeling during healthy aging assessed by cardiovascular magnetic resonance.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Sex-Specific Association of Left Ventricular Hypertrophy With Cardiovascular Events in High-Risk of Cardiovascular Disease Population: Findings From the Sub-Cohort of China PEACE Million Persons Project.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Specificities of Myocardial Infarction and Heart Failure in Women.Journal of clinical medicine · 2024Review
- Influence of hypertension and global or abdominal obesity on left ventricular hypertrophy: A cross-sectional study.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- AI-Derived Left Ventricular Mass From Noncontrast Cardiac CT: Correlation With Contrast CT Angiography and CMR.JACC. Advances · 2024Article
- The Pandora's Box of Hypertensive Heart Disease in Women.JACC. Advances · 2024Article
- Quadratic stratification of left ventricular hypertrophy and association with mitral insufficiency grading: a retrospective study using cardiac magnetic resonance.Cardiovascular diagnosis and therapy · 2024Article
- AI-Defined Cardiac Anatomy Improves Risk Stratification of Hybrid Perfusion Imaging.JACC. Cardiovascular imaging · 2024Article
- Relationship between four insulin resistance surrogates and left ventricular hypertrophy among hypertensive adults: a case-control study.Endocrine connections · 2024Article
- Construction and validation of a nomogram to predict left ventricular hypertrophy in low-risk patients with hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Myocardial mechanical function measured by cardiovascular magnetic resonance in patients with heart failure.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Article
- The role of left ventricular hypertrophy measured by echocardiography in screening patients with ischaemia with non-obstructive coronary arteries: a cross-sectional study.The international journal of cardiovascular imaging · 2023Article
- Plasma Proteomic Patterns Show Sex Differences in Early Concentric Left Ventricular Remodeling.Circulation. Heart failure · 2023Article
- Combined superposition effect of hypertension and dyslipidemia on left ventricular hypertrophy.Animal models and experimental medicine · 2022Article
- Relationship of body fat and left ventricular hypertrophy with the risk of all-cause death in patients with coronary artery disease.Journal of geriatric cardiology : JGC · 2022Article
- Influence of Sex-Based Differences in Cardiac Phenotype on Atrial Fibrillation Recurrence in Patients Undergoing Pulmonary Vein Isolation.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsLeft ventricular hypertrophy (LVH) is the most common form of myocardial remodelling and predicts adverse outcomes in patients with coronary artery disease (CAD). However, sex-specific prevalence and prognostic significance of LVH patterns are poorly understood. We investigated the sex-specific influence of LVH pattern on clinical outcomes in patients undergoing cardiovascular magnetic resonance (CMR) and coronary angiography following adjustment for co-morbidities including CAD burden. METHODS AND
resultsPatients undergoing CMR and coronary angiography between 2005 and 2013 were included. Volumetric measurements of left ventricular (LV) mass with classification of concentric vs. eccentric remodelling patterns were determined from CMR cine images. Multivariable Cox analysis was performed to assess independent associations with the primary outcome of all-cause mortality. In total, 3754 patients were studied (mean age 59.3 ± 13.1 years), including 1039 (27.7%) women. Women were more likely to have concentric remodelling (8.1% vs. 2.1%, P < 0.001), less likely to have eccentric hypertrophy (15.1% vs. 26.8%, P < 0.001) and had a similar prevalence of concentric hypertrophy (6.1 vs. 5.2%, P = 0.296) compared to men. At a median follow-up of 3.7 years, 315 (8.4%) patients died. Following adjustment including CAD burden, concentric hypertrophy was associated with increased all-cause mortality in women [adjusted hazard ratio (HR) 3.48, P < 0.001] and men (adjusted HR 2.57, P < 0.001). Eccentric hypertrophy was associated with all-cause mortality only in women (adjusted HR 1.78, P = 0.047).
conclusionPatterns of LV remodelling differ by sex and LVH and provides prognostic information in both men and women. Our findings support the presence of sex-specific factors influencing LV remodelling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.