ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Distribution of Transmission Potential During Nonsevere COVID-19 Illness.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04802408 (SARS-Cov-2), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- The relationship between COVID-19 viral load and disease severity: A systematic review.Immunity, inflammation and disease · 2022Pooled it
- Pooled it
- Pooled it
- Comprehensive Analysis of COVID-19 Symptomatology among Healthcare Workers: Insights from a Tertiary Hospital.Maedica · 2024Article
- Diagnostic performance of rapid antigen tests (RAT) for COVID-19 and factors associated with RAT-negative results among RT-PCR-positive individuals during Omicron BA.2, BA.5 and XBB.1 predominance.BMC infectious diseases · 2024Article
- Intra-host mutation rate of acute SARS-CoV-2 infection during the initial pandemic wave.Virus genes · 2023Article
- Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort study.The Lancet. Respiratory medicine · 2022Article
- EpiRegress: A Method to Estimate and Predict the Time-Varying Effective Reproduction Number.Viruses · 2022Article
- The Aerosolization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Phase I.The Journal of surgical research · 2022Article
- Quantitative and ultrasensitive in situ immunoassay technology for SARS-CoV-2 detection in saliva.Science advances · 2022Article
- Persistence of clinically relevant levels of SARS-CoV2 envelope gene subgenomic RNAs in non-immunocompromised individuals.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Modelling upper respiratory viral load dynamics of SARS-CoV-2.BMC medicine · 2022Article
- Epidemiological and Clinical Characteristics of Hospitalized Pediatric Patients with SARS-CoV-2 Infection in Mexico City, Mexico.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Article
- Establishment of a reverse transcription real-time quantitative PCR method for Getah virus detection and its application for epidemiological investigation in Shandong, China.Frontiers in microbiology · 2022Article
- Iota-Carrageenan Inhibits Replication of SARS-CoV-2 and the Respective Variants of Concern Alpha, Beta, Gamma and Delta.International journal of molecular sciences · 2021Article
- In vivo kinetics of SARS-CoV-2 infection and its relationship with a person's infectiousness.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Different dynamics of mean SARS-CoV-2 RT-PCR Ct values between the first and second COVID-19 waves in the Madrid population.Transboundary and emerging diseases · 2021Article
- Efficiency of National Taskforce for Combating the Coronavirus (COVID-19) Protocol using real-time PCR testing in health facilities over a period of 8-weeks.Journal of infection and public health · 2021Article
- Performance of the Abbott ID NOW rapid SARS-CoV-2 amplification assay in relation to nasopharyngeal viral RNA loads.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2021Article
- In vivo kinetics of SARS-CoV-2 infection and its relationship with a person's infectiousness.medRxiv : the preprint server for health sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients recovering from coronavirus disease 2019 (COVID-19) often continue to test positive for the causative virus by polymerase chain reaction (PCR) even after clinical recovery, thereby complicating return-to-work plans. The purpose of this study was to evaluate transmission potential of COVID-19 by examining viral load with respect to time.
methodsHealth care personnel (HCP) at Cleveland Clinic diagnosed with COVID-19, who recovered without needing hospitalization, were identified. Threshold cycles (Ct) for positive PCR tests were obtained and viral loads calculated. The association of viral load with days since symptom onset was examined in a multivariable regression model, which was reduced by stepwise backward selection to only keep variables significant at a level of .05. Viral loads by day since symptom onset were predicted using the model and transmission potential evaluated by examination of a viral load-time curve.
resultsOver 6 weeks, 230 HCP had 528 tests performed. Viral loads declined by orders of magnitude within a few days of symptom onset. The only variable significantly associated with viral load was time since onset of symptoms. Of the area under the curve (AUC) spanning symptom onset to 30 days, 96.9% lay within the first 7 days, and 99.7% within 10 days. Findings were very similar when validated using split-sample and 10-fold cross-validation.
conclusionsAmong patients with nonsevere COVID-19, viral loads in upper respiratory specimens peak by 2 or 3 days from symptom onset and decrease rapidly thereafter. The vast majority of the viral load-time AUC lies within 10 days of symptom onset.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.