ArticleEnvironmental research2020
Iron-rich air pollution nanoparticles: An unrecognised environmental risk factor for myocardial mitochondrial dysfunction and cardiac oxidative stress.
Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
37 citing papers in PubMed, 122 citations in OpenAlex.
- Air quality and health implications of exposure to ultrafine particle pollution.Cardiovascular research · 2026Article
- Steroid Biosynthesis Pathway Counteracts Iron Overload-Induced Ferroptosis in Mouse Granulosa Cells.Biology · 2026Article
- Cardio Protective Role of Graphene-based FeCell biochemistry and biophysics · 2026Article
- Extreme Weather Events, Air Pollution, and Cardiovascular Health: Mechanisms and Challenges.Reviews in cardiovascular medicine · 2026Review
- Adherence of traffic-related particles to human red blood cellsERJ open research · 2026Article
- Influence of e-cigarettes and their constituents on cardiac rhythm and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2026Review
- PMAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Are "Clean" Days Really Clean? Single Particle Elemental Signatures of PMEnvironment & health (Washington, D.C.) · 2025Article
- The potential adverse human health effects of metal-containing nanoparticles: a scoping review.Journal of occupational medicine and toxicology (London, England) · 2025Review
- Differential inflammation, oxidative stress and cardiovascular damage markers of nano- and micro-particle exposure in mice: Implications for human disease burden.Redox biology · 2025Article
- Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review.Small science · 2025Review
- Individual effects and interactions between ultrafine particles and extreme temperatures on hospital admissions of high burden diseases.Environment international · 2025Article
- Seasonal Changes in the Oxidative Potential of Urban Air Pollutants: The Influence of Emission Sources and Proton- and Ligand-Mediated Dissolution of Transition Metals.ACS ES&T air · 2024Article
- Copper, Iron, Cadmium, and Arsenic, All Generated in the Universe: Elucidating Their Environmental Impact Risk on Human Health Including Clinical Liver Injury.International journal of molecular sciences · 2024Review
- Metal concentrations and KIM-1 levels in school-aged children: a cross-sectional study.Scientific reports · 2024Article
- Article
- Plant Iron Research in African Countries: Current "Hot Spots", Approaches, and Potentialities.Plants (Basel, Switzerland) · 2023Review
- Iron and iron-related proteins in COVID-19.Clinical and experimental medicine · 2023Review
- Nanomaterials: a review of emerging contaminants with potential health or environmental impact.Discover nano · 2023Review
- Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of FeInternational journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to particulate air pollution is a major environmental risk factor for cardiovascular mortality and morbidity, on a global scale. Both acute and chronic cardiovascular impacts have so far been attributed to particulate-mediated oxidative stress in the lung and/or via 'secondary' pathways, including endothelial dysfunction, and inflammation. However, increasing evidence indicates the translocation of inhaled nanoparticles to major organs via the circulation. It is essential to identify the composition and intracellular targets of such particles, since these are likely to determine their toxicity and consequent health impacts. Of potential major concern is the abundant presence of iron-rich air pollution nanoparticles, emitted from a range of industry and traffic-related sources. Bioreactive iron can catalyse formation of damaging reactive oxygen species, leading to oxidative stress and cell damage or death. Here, we identify for the first time, in situ, that exogenous nanoparticles (~15-40 nm diameter) within myocardial mitochondria of young, highly-exposed subjects are dominantly iron-rich, and co-associated with other reactive metals including aluminium and titanium. These rounded, electrodense nanoparticles (up to ~ 10 x more abundant than in lower-pollution controls) are located within abnormal myocardial mitochondria (e.g. deformed cristae; ruptured membranes). Measurements of an oxidative stress marker, PrP
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.