Evidence map›Paper›PMID 32593787›Full record

ArticlePharmacology, biochemistry, and behavior2020

Effort-related decision making in humanized COMT mice: Effects of Val

Jen-Hau Yang, Rose E Presby, Suzanne Cayer, Renee A Rotolo, Peter A Perrino, R Holly Fitch, Merce Correa, Elissa J Chesler, John D Salamone

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jen-Hau YangBehavioral Neuroscience Division, Department of Psychology, University of Connecticut, Storrs, CT, USA; Present address: Dept. of Psychiatry, Yale University, New Haven, CT, USA.
Rose E PresbyBehavioral Neuroscience Division, Department of Psychology, University of Connecticut, Storrs, CT, USA.
Suzanne CayerBehavioral Neuroscience Division, Department of Psychology, University of Connecticut, Storrs, CT, USA.
Renee A RotoloBehavioral Neuroscience Division, Department of Psychology, University of Connecticut, Storrs, CT, USA.
Peter A PerrinoBehavioral Neuroscience Division, Department of Psychology, University of Connecticut, Storrs, CT, USA.
R Holly FitchBehavioral Neuroscience Division, Department of Psychology, University of Connecticut, Storrs, CT, USA.
Merce CorreaBehavioral Neuroscience Division, Department of Psychology, University of Connecticut, Storrs, CT, USA; Area de Psicobiologia, Universitat Jaume I, Castelló, Spain.
Elissa J CheslerThe Jackson Laboratory, 600 Main St., Bar Harbor, ME 04609, USA.
John D SalamoneBehavioral Neuroscience Division, Department of Psychology, University of Connecticut, Storrs, CT, USA. Electronic address: john.salamone@uconn.edu.
University of Connecticut · USJackson Laboratory · USYale University · US

Funding

Project 5: Circadian RhythmsP50DA039841 · NIDA · JACKSON LABORATORY · PI LAURA G REINHOLDT · 2016 to 2026
$26.2M
Discovery of Addiction-Related Genes with Advanced Mouse ResourcesR01DA037927 · NIDA · JACKSON LABORATORY · PI CHESLER, ELISSA J · 2015 to 2025
$8.1M
NIDA NIH HHS P50 DA039841NIDA NIH HHS R01 DA037927
6 · The paper itself

Abstract

Catechol-o-methyltransferase (COMT) is an enzyme that metabolizes catecholamines, and is crucial for clearance of dopamine (DA) in prefrontal cortex. Val

Indexed as

Decision MakingPolymorphism, GeneticAnimalsAuditory PerceptionCatechol O-MethyltransferaseHumansMaleMethionineMiceMice, TransgenicValineCatechol O-MethyltransferaseCOMT protein, humanMethionineValineCatecholamineChoiceDepressionMetabolismMotivationOperantSchizophrenia

Identifiers

PMID32593787
PMCPMC9182412
OpenAlexW3037807887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.