Evidence map›Paper›PMID 32593740›Full record

ArticleMolecular and cellular endocrinology2020

Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture.

Miriane de Oliveira, Maria Teresa De Sibio, Lucas Solla Mathias, Bruna Moretto Rodrigues, Marna Eliana Sakalem, Célia Regina Nogueira

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Adipocyte · 2023
    Article
  11. Review
  12. Article
  13. Adamalysins in COVID-19 - Potential mechanisms behind exacerbating the disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Review
  14. Resistance Training before, during, and after COVID-19 Infection: What Have We Learned So Far?International journal of environmental research and public health · 2022
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Irisin, Exercise, and COVID-19.Frontiers in endocrinology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Miriane de OliveiraDepartment of Internal Clinic, Botucatu Medicine School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil. Electronic address: miriane.oliveira@unesp.br.
Maria Teresa De SibioDepartment of Internal Clinic, Botucatu Medicine School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Lucas Solla MathiasDepartment of Internal Clinic, Botucatu Medicine School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Bruna Moretto RodriguesDepartment of Internal Clinic, Botucatu Medicine School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Marna Eliana SakalemDepartment of Anatomy, Londrina State University (UEL), Londrina, Parana, Brazil.
Célia Regina NogueiraDepartment of Internal Clinic, Botucatu Medicine School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade Estadual de Londrina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity patients are more susceptible to develop COVID-19 severe outcome due to the role of angiotensin-converting enzyme 2 (ACE2) in the viral infection. ACE2 is regulated in the human cells by different genes associated with increased (TLR3, HAT1, HDAC2, KDM5B, SIRT1, RAB1A, FURIN and ADAM10) or decreased (TRIB3) virus replication. RNA-seq data revealed 14857 genes expressed in human subcutaneous adipocytes, including genes mentioned above. Irisin treatment increased by 3-fold the levels of TRIB3 transcript and decreased the levels of other genes. The decrease in FURIN and ADAM10 expression enriched diverse biological processes, including extracellular structure organization. Our results, in human subcutaneous adipocytes cell culture, indicate a positive effect of irisin on the expression of multiple genes related to viral infection by SARS-CoV-2; furthermore, translatable for other tissues and organs targeted by the novel coronavirus and present, thus, promising approaches for the treatment of COVID-19 infection as therapeutic strategy to decrease ACE2 regulatory genes.

Indexed as

ADAM10 ProteinAdipocytesAmyloid Precursor Protein SecretasesAngiotensin-Converting Enzyme 2BetacoronavirusCell Cycle ProteinsCells, CulturedCoronavirus InfectionsCOVID-19FibronectinsFurinGene Expression RegulationGene OntologyHistone AcetyltransferasesHistone Deacetylase 2HumansACE2 protein, humanADAM10 ProteinADAM10 protein, humanAmyloid Precursor Protein SecretasesAngiotensin-Converting Enzyme 2Cell Cycle ProteinsFibronectinsFNDC5 protein, humanFurinFURIN protein, humanHDAC2 protein, humanHistone Acetyltransferaseshistone acetyltransferase type B complexHistone Deacetylase 2Jumonji Domain-Containing Histone DemethylasesKDM5B protein, humanMembrane ProteinsNuclear ProteinsPeptidyl-Dipeptidase AProtein Serine-Threonine KinasesRAB1A protein, humanrab1 GTP-Binding ProteinsRepressor ProteinsSIRT1 protein, humanSirtuin 1TLR3 protein, humanToll-Like Receptor 3TRIB3 protein, humanADAM10Adipose tissueFURINIrisinSARS-CoV-2TRIB3

Identifiers

PMID32593740
PMCPMC7315947
OpenAlexW3037323216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.