Trial reportBMC anesthesiology2020
High-flow nasal cannula improves clinical efficacy of airway management in patients undergoing awake craniotomy.
Trial report in BMC anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review.Critical care (London, England) · 2023Pooled it
- Oxygen reserve index monitoring reduced the incidence of low pulse oxygen saturation during deep sedation for hysteroscopy: a prospective randomized controlled trial.Frontiers in medicine · 2026Trial
- High-Flow Nasal Oxygen in Contemporary Airway Management: Enhancing Physiological Safety in Anaesthesia-A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- High-flow oxygen delivery system and oxygen reserve index-guided apnoeic oxygenation versus low-tidal-volume ventilation during robotic flexible ureteroscopy: A retrospective cohort study.Indian journal of anaesthesia · 2026Article
- High-Flow Nasal Cannula Oxygen Therapy in Perioperative Respiratory Care: Application and Prospects.Journal of multidisciplinary healthcare · 2026Review
- Stereotactic Brain Biopsy with Awake Craniotomy: Our Awake Craniotomy Experience on a Complicated Case and Mini Review.Turkish journal of anaesthesiology and reanimation · 2025Article
- Practical guidance for monitored anesthesia care during awake craniotomy.Anesthesia and pain medicine · 2025Review
- Article
- High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation: a randomised controlled trial.Perioperative medicine (London, England) · 2023Article
- A propensity score-adjusted analysis of efficacy of high-flow nasal oxygen during awake tracheal intubation.Scientific reports · 2022Article
- Should We Use High-Flow Nasal Cannula in Patients Receiving Gastrointestinal Endoscopies? Critical Appraisals through Updated Meta-Analyses with Multiple Methodologies and Depiction of Certainty of Evidence.Journal of clinical medicine · 2022Review
- High-flow nasal cannula oxygenation for awake craniotomy in patients with obesity: looking beyond oxygenation.Anesthesia and pain medicine · 2022Article
- Mechanical Bowel Preparation Is a Risk Factor for Postoperative Delirium as It Alters the Gut Microbiota Composition: A Prospective Randomized Single-Center Study.Frontiers in aging neuroscience · 2022Article
- Trans-nasal humidified rapid insufflation ventilatory exchange (THRIVE) in neuroanesthesia practice: A review.Journal of anaesthesiology, clinical pharmacologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAwake craniotomy requires specific sedation procedure in an awake patient who should be able to cooperate during the intraoperative neurological assessment. Currently, limited number of literatures on the application of high-flow nasal cannula (HFNC) in the anesthetic management for awake craniotomy has been reported. Hence, we carried out a prospective study to assess the safety and efficacy of humidified high-flow nasal cannula (HFNC) airway management in the patients undergoing awake craniotomy.
methodsSixty-five patients who underwent awake craniotomy were randomly assigned to use HFNC with oxygen flow rate at 40 L/min or 60 L/min, or nasopharynx airway (NPA) device in the anesthetic management. Data regarding airway management, intraoperative blood gas analysis, intracranial pressure, gastric antral volume, and adverse events were collected and analyzed.
resultsPatients using HFNC with oxygen flow rate at 40 or 60 L/min presented less airway obstruction and injuries. Patients with HFNC 60 L/min maintained longer awake time than the patients with NPA. While the intraoperative PaO
conclusionHFNC was safe and effective for the patients during awake craniotomy.
trial registrationChinese Clinical Trial Registry, CHiCTR1800016621 . Date of Registration: 12 June 2018.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.