ArticleMedical hypotheses2020
Is periodontal disease a risk factor for severe COVID-19 illness?
Article in Medical hypotheses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Prevalence, Features and Degree of Association of Oral Lesions in COVID-19: A Systematic Review of Systematic Reviews.International journal of environmental research and public health · 2022Pooled it
- Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Current Landscape of the Interrelationship Between Periodontitis, Type 2 Diabetes Mellitus, and COVID-19.International journal of molecular sciences · 2025Review
- Periodontal Disease Elevates IL-6 Levels During Initial Symptoms of COVID-19.Diagnostics (Basel, Switzerland) · 2025Article
- Association of self-reported periodontal disease and inequities with long haul COVID-19.PloS one · 2024Article
- Periodontitis Continuum: Antecedents, Triggers, Mediators, and Treatment Strategies.Current medicinal chemistry · 2024Review
- Proposed Mechanisms for the Relationship between Periodontal Diseases and the Severity of Covid-19: Common Pathogens, Inflammatory Mediators, and Risk Factors.Advanced biomedical research · 2024Review
- Unraveling the Link between Periodontitis and Coronavirus Disease 2019: Exploring Pathogenic Pathways and Clinical Implications.Biomedicines · 2023Review
- Association between periodontal diseases and COVID-19 infection: a case-control study with a longitudinal arm.Odontology · 2023Article
- Association between periodontal diseases and COVID-19 infection: a case-control study with a longitudinal arm.Odontology · 2023Article
- Dental calculus - An emerging bio resource for past SARS CoV2 detection, studying its evolution and relationship with oral microflora.Journal of King Saud University. Science · 2023Review
- Periodontal disease and COVID-19: Prognosis and potential pathways of association in their pathogenesis.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2023Review
- Associations between Periodontitis, COVID-19, and Cardiometabolic Complications: Molecular Mechanisms and Clinical Evidence.Metabolites · 2022Review
- Psychological Impact of COVID-19 in the Setting of Dentistry: A Review Article.International journal of environmental research and public health · 2022Review
- Oral Health Interventions: Is it Important for COVID-19 Patients?Asia-Pacific journal of public health · 2022Article
- Self-Reported Periodontal Disease and Its Association with SARS-CoV-2 Infection.International journal of environmental research and public health · 2022Article
- Is There a Link between COVID-19 and Periodontal Disease? A Narrative Review.European journal of dentistry · 2022Article
- Association between Periodontitis and COVID-19 Based on Severity Scores of HRCT Chest Scans.Dentistry journal · 2022Article
- Dental diseases are associated with increased odds ratio for coronavirus disease 19.Oral diseases · 2022Article
- The Association between the Oral-Gut Axis and the Outcomes of Severe COVID-19 Patients Receiving Extracorporeal Membrane Oxygenation: A Case-Control Study.Journal of clinical medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal disease (PD) comprises a group of diseases involving inflammatory aspects of the host and dysbiotic events that affect periodontal tissues and could have systemic implications. Diverse factors and comorbidities have been closely associated with PD such as diabetes, obesity, aging, hypertension, and so on; although, underlying mechanisms or causal associations have not been established completely. Interestingly, these same factors have been widely associated with progression or severe coronavirus disease 2019 (COVID-19), an illness caused by coronavirus SARS-CoV-2. Since inflammatory and dysbiotic factors as well as comorbidities affect systemic health, it is possible that periodontal status indicates the risk of complication of COVID-19. However, assessment of oral health history including periodontal status in COVID-19 patients has not been reported. Knowing PD is associated with severe COVID-19 could help identify risk groups and establish pertinent recommendations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.