Trial reportJournal of cardiac failure2020
In-Hospital Management of Sleep Apnea During Heart Failure Hospitalization: A Randomized Controlled Trial.
Trial report in Journal of cardiac failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- The Impact of Risk Factors and Comorbidities on Heart Failure in the Aging Population.International journal of molecular sciences · 2026Review
- Continuous positive airway pressure on left ventricular ejection fraction in obstructive sleep apnea and heart failure with reduced ejection fraction: a systematic review and meta-analysis.Sleep and biological rhythms · 2026Article
- Acute Heart Failure and Central Sleep Apnea.Sleep medicine clinics · 2025Review
- [Heart and sleep: a strong team! : Cardiovascular effects of sleep-disordered breathing and its treatment].Innere Medizin (Heidelberg, Germany) · 2025Review
- Positive Airway Pressure Therapies for Heart Failure: What Do the Trials Tell Us?Cardiac failure review · 2025Review
- Predicting heart failure symptoms from the apnoea-hypopnoea index determined by full- night polysomnography.ESC heart failure · 2024Article
- Interactions of Obstructive Sleep Apnea With the Pathophysiology of Cardiovascular Disease, Part 1: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2024Review
- CPAP Treatment at Home after Acute Decompensated Heart Failure in Patients with Obstructive Sleep Apnea.Journal of clinical medicine · 2024Article
- Clinical and financial impact of sleep disordered breathing on heart failure admissions.Sleep & breathing = Schlaf & Atmung · 2023Article
- Association between Obstructive Sleep Apnea and Heart Failure in Adults-A Systematic Review.Journal of clinical medicine · 2023Review
- Breathe Better and Preserve Heart.Journal of the American Heart Association · 2023Article
- Assessment of sleep disordered breathing in patients with heart failure.Breathe (Sheffield, England) · 2022Article
- Obstructive Sleep Apnea in Heart Failure: Current Knowledge and Future Directions.Journal of clinical medicine · 2022Review
- Prognostic effect of sleep-disordered breathing on hospitalized patients following acute heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Article
- Does testing for sleep-disordered breathing predischarge vs postdischarge result in different treatment outcomes?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Home sleep apnea testing of adults with chronic heart failure.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundObstructive sleep apnea (OSA) is associated with increased mortality and readmissions in patients with heart failure (HF). The effect of in-hospital diagnosis and treatment of OSA during decompensated HF episodes remains unknown. METHODS AND
resultsA single-site, randomized, controlled trial of hospitalized patients with decompensated HF (n = 150) who were diagnosed with OSA during the hospitalization was undertaken. All participants received guideline-directed therapy for HF decompensation. Participants were randomized to an intervention arm which received positive airway pressure (PAP) therapy during the hospitalization (n = 75) and a control arm (n = 75). The primary outcome was discharge left ventricular ejection fraction (LVEF). The LVEF changed in the PAP arm from 25.5 ± 10.4 at baseline to 27.3 ± 11.9 at discharge. In the control group, LVEF was 27.3 ± 11.7 at baseline and 28.8 ± 10.5 at conclusion. There was no significant effect on LVEF of in-hospital PAP compared with controls (P = .84) in the intention-to-treat analysis. The on-treatment analysis in the intervention arm showed a significant increase in LVEF in participants who used PAP for ≥3 hours per night (n = 36, 48%) compared with those who used it less (P = .01). There was a dose effect with higher hours of use associated with more improvement in LVEF. Follow-up of readmissions at 6 months after discharge revealed a >60% decrease in readmissions for patients who used PAP ≥3 h/night compared with those who used it <3 h/night (P < .02) and compared with controls (P < .04).
conclusionsIn-hospital treatment with PAP was safe but did not significantly improve discharge LVEF in patients with decompensated HF and newly diagnosed OSA. An exploratory analysis showed that adequate use of PAP was associated with higher discharge LVEF and decreased 6 months readmissions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.