ArticleNeuroImage2020
Longitudinal analysis of regional cerebellum volumes during normal aging.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Shaky scaffolding: Age differences in cerebellar activation revealed through activation likelihood estimation meta-analysis.Human brain mapping · 2020Pooled it
- Enhancing Balance Control in Aging Through Cerebellar Theta-Burst Stimulation.Cerebellum (London, England) · 2025Trial
- Age-related degradation of cerebellar functional network topology.GeroScience · 2026Article
- Cerebellar aging is spatially heterogeneous and supports cognitive resilience in later life.Nature neuroscience · 2026Article
- Three parsimonious spatiotemporal patterns in cerebellum reveal individual traits in function and behavior.Nature communications · 2026Article
- Cerebellar gray matter volume difference in first-episode bipolar and unipolar depression.BMC psychiatry · 2026Article
- Mapping cerebellar subregional volumes and heterogeneity in schizophrenia spectrum disorders and violence.European archives of psychiatry and clinical neuroscience · 2026Article
- Article
- Biological Age Prediction of the Cerebellar Vermis in the Human Lifespan.Cerebellum (London, England) · 2025Article
- Predicting Mental and Neurological Illnesses Based on Cerebellar Normative Features.Biological psychiatry global open science · 2025Article
- Glial Cells and Aging: From the CNS to the Cerebellum.International journal of molecular sciences · 2025Review
- Cerebellar Brain Inhibition and Its Association with Motor Inhibition and Reaction Time In Younger and Older Adults.Cerebellum (London, England) · 2025Article
- Mapping Cerebellar Morphology in 15q11.2 CNV Carriers Using Normative Modeling.medRxiv : the preprint server for health sciences · 2025Article
- Aging Impacts Basic Auditory and Timing Processes.The European journal of neuroscience · 2025Article
- GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups.Frontiers in aging neuroscience · 2025Article
- Functional and structural cerebellar-behavior relationships in aging.Brain structure & function · 2024Article
- Cerebellar Structural and N-Acetylaspartate, Choline, and Creatine Metabolic Profiles in Parkinson's Disease and Essential Tremor.Diagnostics (Basel, Switzerland) · 2024Article
- Cerebello-Hippocampal Interactions in the Human Brain: A New Pathway for Insights Into Aging.Cerebellum (London, England) · 2024Review
- Heritability of cerebellar subregion volumes in adolescent and young adult twins.Human brain mapping · 2024Article
- Consensus Paper: Cerebellum and Ageing.Cerebellum (London, England) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Some cross-sectional studies suggest reduced cerebellar volumes with aging, but there have been few longitudinal studies of age changes in cerebellar subregions in cognitively healthy older adults. In this work, 2,023 magnetic resonance (MR) images of 822 cognitively normal participants from the Baltimore Longitudinal Study of Aging (BLSA) were analyzed. Participants ranged in age from 50 to 95 years (mean 70.7 years) at the baseline assessment. Follow-up intervals were 1-9 years (mean 3.7 years) for participants with two or more visits. We used a recently developed cerebellum parcellation algorithm based on convolutional neural networks to divide the cerebellum into 28 subregions. Linear mixed effects models were applied to the volume of each cerebellar subregion to investigate cross-sectional and longitudinal age effects, as well as effects of sex and their interactions, after adjusting for intracranial volume. Our findings suggest spatially varying atrophy patterns across the cerebellum with respect to age and sex both cross-sectionally and longitudinally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.