Evidence map›Paper›PMID 32592683›Full record

ArticleActa tropica2020

Blending studies with selected waterbuck odor constituents or analogues in the development of a potent repellent blend against savannah tsetse.

Benson M Wachira, Joy M Kabaka, Paul O Mireji, Sylvance O Okoth, Margaret M Ng'ang'a, Grace A Murilla, Ahmed Hassanali

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta tropica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Benson M WachiraDepartment of Chemistry, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844-00100, Nairobi, Kenya; Biotechnology Research Institute - Kenya Agricultural and Livestock Research Organization, P.O. Box 362-00902, Kikuyu, Kenya. Electronic address: wachirabenson3@gmail.com.
Joy M KabakaDepartment of Biochemistry and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844-00100, Nairobi, Kenya.
Paul O MirejiBiotechnology Research Institute - Kenya Agricultural and Livestock Research Organization, P.O. Box 362-00902, Kikuyu, Kenya; Centre for Geographic Medicine Research - Coast, Kenya Medical Research Institute, P.O. Box 230-80108, Kilifi, Kenya. Electronic address: mireji.paul@gmail.com.
Sylvance O OkothBiotechnology Research Institute - Kenya Agricultural and Livestock Research Organization, P.O. Box 362-00902, Kikuyu, Kenya.
Margaret M Ng'ang'aDepartment of Chemistry, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844-00100, Nairobi, Kenya.
Grace A MurillaBiotechnology Research Institute - Kenya Agricultural and Livestock Research Organization, P.O. Box 362-00902, Kikuyu, Kenya.
Ahmed HassanaliDepartment of Chemistry, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844-00100, Nairobi, Kenya.
Kenya Agricultural and Livestock Research Organization · KEKenyatta University · KEKenya Medical Research Institute · KE

Funding

Molecular and functional characterization of olfaction genes in tsetse fliesR03TW009444 · FIC · YALE UNIVERSITY · PI AKSOY, SERAP · 2013 to 2015
$157k
FIC NIH HHS R03 TW009444
6 · The paper itself

Abstract

Previous comparison of the body odors of tsetse-refractory waterbuck and those of tsetse-attractive ox and buffalo showed that a blend of 15 EAG-active compounds specific to waterbuck, including C5-C10 straight chain carboxylic acid homologues, methyl ketones (C8-C12 straight chain homologues and geranyl acetone), phenols (guaiacol and carvacrol) and δ-octalactone, was repellent to tsetse. A blend of four components selected from each class of compounds (δ-octalactone, pentanoic acid, guaiacol, and geranylacetone) showed repellence that is comparable to that of the 15 components blend and can provide substantial protection to cattle (more than 80%) from tsetse bites and trypanosome infections. Structure-activity studies with the lactone and phenol analogues showed that δ-nonalactone and 4-methylguaiacol are significantly more repellent than δ-octalactone and guaiacol, respectively. In the present study, we compared the responses of Glossina pallidipes and Glossina morsitans to i) blends comprising of various combinations of the most active analogues from each class of compounds, and ii) a four-component blend of δ-nonalactone, heptanoic acid, 4-methylguaiacol and geranyl acetone in different ratios in a two-choice wind-tunnel, followed by a field study with G. pallidipes population in a completely randomized Latin Square Design set ups. In the wind tunnel experiments, the blend of the four compounds in 6:4:2:1 ratio was found to be significantly more repellent (94.53%) than that in 1:1:1:1 proportion and those in other ratios. G. m. morsitans also showed a similar pattern of results. In field experiments with G. pallidipes population, the 6:4:2:1 blend of the four compounds also gave similar results. The results lay down useful groundwork in the large-scale development of more effective 'push' and 'push-pull' control tactics of the tsetse flies.

Indexed as

AntelopesOdorantsAnimalsCattleCresolsInsect ControlInsect RepellentsMaleTsetse FliescreosolCresolsInsect RepellentsBlending studies‘push’-tacticSavanna tsetseTsetse-repellency

Identifiers

PMID32592683
PMCPMC10895417
OpenAlexW3037907462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.