Evidence map›Paper›PMID 32592660›Full record

ArticleJournal of the American College of Radiology : JACR2020

Multi-Institutional Assessment and Crowdsourcing Evaluation of Deep Learning for Automated Classification of Breast Density.

Ken Chang, Andrew L Beers, Laura Brink, Jay B Patel, Praveer Singh, Nishanth T Arun, Katharina V Hoebel, Nathan Gaw, Meesam Shah, Etta D Pisano and 6 more

Abstract read
In one paragraph

Article in Journal of the American College of Radiology : JACR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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  13. Collaborative Privacy-preserving Approaches for Distributed Deep Learning Using Multi-Institutional Data.Radiographics : a review publication of the Radiological Society of North America, Inc · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ken ChangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
Andrew L BeersAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
Laura BrinkAmerican College of Radiology, Reston, Virginia.
Jay B PatelAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
Praveer SinghAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
Nishanth T ArunAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
Katharina V HoebelAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
Nathan GawAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
Meesam ShahAmerican College of Radiology, Reston, Virginia.
Etta D PisanoChief Research Officer (ACR), Reston, Virginia; Professor in Residence, Beth Israel Lahey/Harvard Medical School, Boston, Massachusetts.
Mike TilkinChief Information Officer and EVP for Technology (ACR), Reston, Virginia.
Laura P CoombsVice President (ACR), Reston, Virginia.
Keith J DreyerChief Data Science Officer, Chief Imaging Information Officer, Massachussetts General Hospital and Brigham Women's Hospital (MGH & BWH), Chief Executive, MGH & BWH Center for Clinical Data Science; Vice Chairman of Radiology - Informatics, MGH & BWH, Boston, Massachusetts; Associate Professor of Radiology,Harvard Medical School, Boston, Massachusetts; Chief Science Officer, ACR Data Science Institute, Reston, Virginia.
Bibb AllenChief Medical Office, ACR Data Science Institute, Reston, Virginia; Secretary General, International Society of Radiology, Reston, Virginia; Partner, Grandview Medical Center, Birmingham, Alabama.
Sheela AgarwalLennox Hill Radiology, New York, New York.
Jayashree Kalpathy-CramerAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts; Scientific Director (CCDS), Director (QTIM lab and the Center for Machine Learning), Associate Professor of Radiology, MGH/Harvard Medical School, Boston, Massachusetts. Electronic address: kalpathy@nmr.mgh.harvard.edu.

Funding

Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Quantitative Image Informatics for Cancer Research (QIICR)U24CA180918 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEDOROV, ANDRIY, KIKINIS, RON · 2013 to 2017
$4.0M
Neuroimaging Training ProgramT32EB001680 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BRUCE R ROSEN · 2003 to 2026
$3.8M
Informatics Tools for Optimized Imaging Biomarkers for Cancer Research&DiscoveryU24CA180927 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KALPATHY-CRAMER, JAYASHREE, ROSEN, BRUCE R · 2014 to 2018
$3.4M
Quantitative MRI of Glioblastoma ResponseU01CA154601 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KALPATHY-CRAMER, JAYASHREE · 2011 to 2016
$3.4M
Distributed Learning of Deep Learning Models for Cancer ResearchU01CA242879 · NCI · STANFORD UNIVERSITY · PI KALPATHY-CRAMER, JAYASHREE, RUBIN, DANIEL L · 2019 to 2021
$1.2M
Automatic Volumetric Treatment Response Assessment and Determination of Regional Genetic Characteristics in GlioblastomaF30CA239407 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHANG, KEN · 2019 to 2020
$101k
NCI NIH HHS F30 CA239407NCI NIH HHS U01 CA154601NCI NIH HHS U01 CA242879NCI NIH HHS U24 CA180918NCI NIH HHS U24 CA180927NIBIB NIH HHS P41 EB015896NIBIB NIH HHS T32 EB001680
6 · The paper itself

Abstract

objectiveWe developed deep learning algorithms to automatically assess BI-RADS breast density.

methodsUsing a large multi-institution patient cohort of 108,230 digital screening mammograms from the Digital Mammographic Imaging Screening Trial, we investigated the effect of data, model, and training parameters on overall model performance and provided crowdsourcing evaluation from the attendees of the ACR 2019 Annual Meeting.

resultsOur best-performing algorithm achieved good agreement with radiologists who were qualified interpreters of mammograms, with a four-class κ of 0.667. When training was performed with randomly sampled images from the data set versus sampling equal number of images from each density category, the model predictions were biased away from the low-prevalence categories such as extremely dense breasts. The net result was an increase in sensitivity and a decrease in specificity for predicting dense breasts for equal class compared with random sampling. We also found that the performance of the model degrades when we evaluate on digital mammography data formats that differ from the one that we trained on, emphasizing the importance of multi-institutional training sets. Lastly, we showed that crowdsourced annotations, including those from attendees who routinely read mammograms, had higher agreement with our algorithm than with the original interpreting radiologists.

conclusionWe demonstrated the possible parameters that can influence the performance of the model and how crowdsourcing can be used for evaluation. This study was performed in tandem with the development of the ACR AI-LAB, a platform for democratizing artificial intelligence.

Indexed as

Breast NeoplasmsCrowdsourcingDeep LearningArtificial IntelligenceBreast DensityFemaleHumansMammographyACR AI-LABartificial intelligenceBI-RADSbreast densitydeep learningDMISTgeneralizabilitymammogramneural networks

Identifiers

PMID32592660
PMCPMC10757768

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.