ArticleCell metabolism2020
In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19.
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Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 300 papers, 9 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
300citing papers in PubMed, 9 pooled it
11.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
300 citing papers in PubMed, 9 syntheses or guidelines pooled it, 498 citations in OpenAlex.
- Renin-Angiotensin Aldosterone System Inhibitors and COVID-19: A Systematic Review and Meta-Analysis Revealing Critical Bias Across a Body of Observational Research.Journal of the American Heart Association · 2022Pooled it
- Association of statin and/or renin-angiotensin-aldosterone system modulating therapy with mortality in adults with diabetes admitted to hospital with COVID-19: A retrospective multicentre European study.Diabetes & metabolic syndrome · 2022 · on this mapPooled it
- The Association Between the Use of Statins and Clinical Outcomes in Patients with COVID-19: A Systematic Review and Meta-analysis.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2022Pooled it
- Acid suppressant use in association with incidence and severe outcomes of COVID-19: a systematic review and meta-analysis.European journal of clinical pharmacology · 2022Pooled it
- The use of statins was associated with reduced COVID-19 mortality: a systematic review and meta-analysis.Annals of medicine · 2021 · on this mapPooled it
- Statins and clinical outcomes with COVID-19: Meta-analyses of observational studies.Diabetes & metabolism · 2021 · on this mapPooled it
- Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Pooled it
- Statin and outcomes of coronavirus disease 2019 (COVID-19): A systematic review, meta-analysis, and meta-regression.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2021 · on this mapPooled it
- In-hospital use of statins is associated with a reduced risk of mortality in coronavirus-2019 (COVID-19): systematic review and meta-analysis.Pharmacological reports : PR · 2021Pooled it
- Baseline Statin Use Appears to Protect Against Severe COVID-19.Open forum infectious diseases · 2024Trial
- Effect of IL-6R blockade on plasma lipids and clinical outcomes among hospitalized patients with COVID-19 infection.Journal of lipid research · 2024Trial
- Trial
- Circulating cholesterol fuels SARS-CoV-2 replication via ORF3a.EMBO reports · 2026Article
- Drug Repurposing as a Broad-Spectrum Strategy Against Coronaviruses: Frontiers in Mechanisms and Clinical Translation.Viruses · 2026Review
- The non-vesicular cholesterol transporter GRAMD1C is a pan-coronavirus antiviral target.PLoS biology · 2026Article
- Targeting the host factor HGS-viral membrane protein interaction in coronavirus infection.The Journal of clinical investigation · 2026Article
- Association Between Statin Use, Cytokine Storm, and Clinical Outcomes in COVID-19 Patients with Diabetes.Biomedicines · 2026Article
- Molecular mechanism of cholesterol-dependent membrane fusion in SARS-CoV-2 entry.Signal transduction and targeted therapy · 2026Article
- Lipid metabolism, viral infection, and antiviral immunity: a new host-pathogen interface.Frontiers in cellular and infection microbiology · 2026Review
- The impact of diabetes and obesity on the severity and mortality of SARS-CoV-2 infection.Journal of diabetes and metabolic disorders · 2025Review
240 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
49 authors at 20 institutions in 4 countries.
Xiao-Jing ZhangDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Juan-Juan QinDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Xu ChengDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Lijun ShenDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Yan-Ci ZhaoDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Yufeng YuanDepartment of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Fang LeiInstitute of Model Animal, Wuhan University, Wuhan, China.
Ming-Ming ChenDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Huilin YangDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Liangjie BaiInstitute of Model Animal, Wuhan University, Wuhan, China.
Xiaohui SongInstitute of Model Animal, Wuhan University, Wuhan, China.
Lijin LinDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Meng XiaInstitute of Model Animal, Wuhan University, Wuhan, China.
Feng ZhouInstitute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jianghua ZhouDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Zhi-Gang SheDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Lihua ZhuDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Xinliang MaDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19004, USA.
Qingbo XuCentre for Clinic Pharmacology, The William Harvey Research Institute, Queen Mary University of London, London, UK.
Ping YeDepartment of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430072, China.
Guohua ChenDepartment of Neurology, Wuhan First Hospital/Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan 430072, China.
Liming LiuDepartment of General Surgery, Ezhou Central Hospital, Ezhou 436000, China.
Weiming MaoDepartment of General Surgery, Huanggang Central Hospital, Huanggang 438000, China.
Youqin YanWuhan Seventh Hospital, Wuhan 430072, China.
Bing XiaoDepartment of Stomatology, Xiantao First People's Hospital, Xiantao 433000, China.
Zhigang LuDepartment of Neurology, The First People's Hospital of Jingmen Affiliated to Hubei Minzu University, Jingmen 448000, China.
Gang PengDepartment of Hepatobiliary and Pancreatic Surgery, Suizhou Central Hospital Affiliated to Hubei Medical College, Suizhou 441300, China.
Mingyu LiuThe Ninth Hospital of Wuhan City, Wuhan 430072, China.
Jun YangDepartment of Cardiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital and Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, China.
Luyu YangDepartment of Intensive Care Unit, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, China.
Changjiang ZhangDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China.
Haofeng LuDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Changjiang University, Jingzhou, China.
Xigang XiaDepartment of Hepatobiliary Surgery, Jingzhou Central Hospital, Jingzhou, China.
Daihong WangDepartment of Hepatobiliary and Pancreatic Surgery, Xianning Central Hospital, Xianning, Hubei Province, China.
Xiaofeng LiaoXiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
Xiang WeiDivision of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Bing-Hong ZhangDepartment of Neonatology, Renmin Hospital of Wuhan University, Wuhan, China.
Xin ZhangInstitute of Model Animal, Wuhan University, Wuhan, China.
Juan YangDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
Guang-Nian ZhaoInstitute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Peng ZhangInstitute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Peter P LiuDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Rohit LoombaNAFLD Research Center, Division of Gastroenterology and Epidemiology, University of California, San Diego, San Diego, CA, USA.
Yan-Xiao JiInstitute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jiahong XiaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: jiahong.xia@hust.edu.cn.
Yibin WangDepartments of Anesthesiology, Physiology, and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: yibinwang@mednet.ucla.edu.
Jingjing CaiDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410000, China. Electronic address: caijingjing83@hotmail.com.
Jiao GuoGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine & Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China & Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China. Electronic address: guoj@gdpu.edu.cn.
Hongliang LiDepartment of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: lihl@whu.edu.cn.
Wuhan University · CNChina Three Gorges University · CNCentral Hospital of Wuhan · CNCentral South University · CNEzhou Central Hospital · CNFirst People’s Hospital of Jingmen · CNFirst People's Hospital of Jingzhou · CNGuangzhou University of Chinese Medicine · CNHuanggang Central Hospital · CNHubei University of Arts and Science · CNJingzhou Central Hospital · CNNantong University · CNQueen Mary University of London · GBSuizhou Central Hospital · CNThomas Jefferson University · USTongji Hospital · CNTongren Hospital · CNUnion Hospital · CNUniversity of California, Los Angeles · USUniversity of California San Diego · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of SARS-CoV-2 viral entry by inducing ACE2 expression. Here, we performed a retrospective study on 13,981 patients with COVID-19 in Hubei Province, China, among which 1,219 received statins. Based on a mixed-effect Cox model after propensity score-matching, we found that the risk for 28-day all-cause mortality was 5.2% and 9.4% in the matched statin and non-statin groups, respectively, with an adjusted hazard ratio of 0.58. The statin use-associated lower risk of mortality was also observed in the Cox time-varying model and marginal structural model analysis. These results give support for the completion of ongoing prospective studies and randomized controlled trials involving statin treatment for COVID-19, which are needed to further validate the utility of this class of drugs to combat the mortality of this pandemic.
Indexed as
AgedAngiotensin-Converting Enzyme 2Angiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsBetacoronavirusComorbidityCoronavirus InfectionsCOVID-19Cytokine Release SyndromeDrug RepositioningDrug Therapy, CombinationFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypertensionMaleACE2 protein, humanAngiotensin-Converting Enzyme 2Angiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsHydroxymethylglutaryl-CoA Reductase InhibitorsPeptidyl-Dipeptidase AACEi/ARBCOVID-19mortalitySARS-COV-2statin
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