ArticleInternational journal of laboratory hematology2020
Manifestations of blood coagulation and its relation to clinical outcomes in severe COVID-19 patients: Retrospective analysis.
Article in International journal of laboratory hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 39 citations in OpenAlex.
- The dynamic role of soluble urokinase plasminogen activator receptor (suPAR) in monitoring coagulation dysfunction during COVID-19 progression: a review.Annals of medicine and surgery (2012) · 2025Review
- Naoxintong Is Involved in the Coagulation Regulation of Warfarin Through the MAPK Pathway.Pharmacogenomics and personalized medicine · 2025Article
- Type 1 diabetes mellitus patients had lower total vitamin K levels and increased sensitivity to direct anticoagulants.PloS one · 2025Article
- Unveiling coagulation dysfunction in patients with COVID-19: a retrospective analysis.Journal of medicine and life · 2024Article
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- High Plasma tPAPAI-1C Levels May Be Related to a Poor Prognosis in Patients with Severe or Critical COVID-19: A Single-Center Retrospective Study.Journal of clinical medicine · 2023Article
- The association between prothrombin time-international normalized ratio and long-term mortality in patients with coronary artery disease: a large cohort retrospective study with 44,662 patients.BMC cardiovascular disorders · 2022Article
- Venous and arterial thrombosis in COVID-19: An updated narrative review.Journal of infection and public health · 2022Review
- Statistical Analysis and Machine Learning Prediction of Disease Outcomes for COVID-19 and Pneumonia Patients.Frontiers in cellular and infection microbiology · 2022Article
- Rays of immunity: Role of sunshine vitamin in management of COVID-19 infection and associated comorbidities.Clinical nutrition ESPEN · 2021Review
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- Innate and Adaptive Immunity Imbalance With Severe COVID-19 Pneumonia in Children and Adults.Frontiers in pediatrics · 2021Article
- Diagnostic and prognostic value of Sepsis-Induced coagulopathy and International Society on Thrombosis and Hemostasis scoring systems in COVID-19-associated disseminated intravascular coagulopathy.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Review
- Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia.PloS one · 2021Observational
- A Retrospective Cohort Study on the Clinical Course of Patients With Moderate-Type COVID-19.Frontiers in public health · 2021Article
- Manifestations of blood coagulation and its relation to clinical outcomes in severe COVID-19 patients: Retrospective analysis.International journal of laboratory hematology · 2020Article
- Coronavirus Disease-19: Challenges Associated with the Treatment of Head and Neck Oncology and Laryngology Patients in the Coronavirus Disease-19 Era.Otolaryngologic clinics of North America · 2020Review
- A nomogramic model based on clinical and laboratory parameters at admission for predicting the survival of COVID-19 patients.BMC infectious diseases · 2020Article
- Therapeutic strategies against COVID-19.Acta bio-medica : Atenei Parmensis · 2020Review
- Coagulation Biomarkers and Mortality in Severe COVID-19: The Prognostic Value of Factor XIII Decline and Elevated D-Dimers.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
introductionCharacteristics of blood coagulation and its relation to clinical outcomes in COVID-19 patients are still rarely reported. We aimed to investigate the blood coagulation function and its influences on clinical outcomes of patients with syndrome coronavirus 2 (SARS-CoV-2) infection.
methodsA total of 71 severe patients with confirmed SARS-CoV-2 infection who were treated in Wuhan First Hospital from February 12 to March 20, 2020, were enrolled. The blood coagulation data in these patients and in 61 healthy controls were collected. The patients with COVID-19 were divided into two groups: the aggravated group and the nonaggravated group, respectively, basing on whether the patients' conditions turned to critically ill or not after admission.
resultsCompared with healthy controls, patients with COVID-19 had significant performances with coagulation dysfunction, including dramatically elevated values of FIB, PT, APTT, INR, FDP, and D-Dimers but markedly reduced AT value (P < .05). Importantly, more noteworthy coagulation disorders similar to the differences between patients and controls were found in the aggravated patients with conditions deterioration after admission than those in the nonaggravated patients without conditions deterioration (P < .05). Moreover, the aggravated patients possessed a longer hospital stay and a higher mortality compared with the nonaggravated patients (P < .001). The coagulation parameters of COVID-19 patients were widely and closely related to the indexes of liver function and inflammation (P < .05), indicating the coagulation dysfunction of these patients may be caused by liver injury and inflammatory storm.
conclusionSevere patients with SARS-CoV-2 infection often possess coagulation dysfunction on admission. A certain correlation exists in coagulation disorder and adverse clinical outcome among severe COVID-19 patients.
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