Evidence map›Paper›PMID 32592408›Full record

ReviewHematological oncology2020

Illuminating novel biological aspects and potential new therapeutic approaches for chronic myeloproliferative malignancies.

Tariq I Mughal, Naveen Pemmaraju, Bethan Psaila, Jerald Radich, Prithviraj Bose, Thomas Lion, Jean-Jacques Kiladjian, Raajit Rampal, Tania Jain, Srdnan Verstovsek and 5 more

Open access · hybridAbstract readReview
In one paragraph

Review in Hematological oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 5 countries.

Tariq I MughalTufts University Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-1005-7724
Naveen PemmarajuMD Anderson Cancer Center, Houston, Texas, USA.
Bethan PsailaMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Jerald RadichFrederick Hutchinson Cancer Research Center, Seattle, Washington, USA.
Prithviraj BoseMD Anderson Cancer Center, Houston, Texas, USA.
Thomas LionChildrens Cancer Research Institute, Vienna, Austria.
Jean-Jacques KiladjianHôpital Saint-Louis, Université de Paris, Paris, France.
Raajit RampalMemorial Sloan Kettering Cancer Center, New York, New York, USA.
Tania JainSidney Kimmel Cancer Center, John Hopkins Hospital, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-6854-773X
Srdnan VerstovsekMD Anderson Cancer Center, Houston, Texas, USA.
Abdulraheem YacoubDivision of Hematologic Malignancies, University of Kansas, Kansas City, Kansas, USA.
Jorge E CortesGeorgia Cancer Center, Augusta University, Augusta, Georgia, USA.
Ruben MesaMays Cancer Center at UT Health San Antonio MD Anderson, San Antonio, Texas, USA.
Giuseppe SaglioOrbassano University Hospital, Turin, Italy.
Richard A van EttenUniversity of California Irvine, Irvine, California, USA.
The University of Texas MD Anderson Cancer Center · USAugusta University Health · USCancer Research Institute of the Slovak Academy of Sciences · SKFred Hutch Cancer Center · USMemorial Sloan Kettering Cancer Center · USSidney Kimmel Cancer Center · USTufts University · USUniversité Paris Cité · FRUniversity of California, Irvine · USUniversity of Kansas · USUniversity of Oxford · GB

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
Cancer Research UK 28051Cancer Research UK 29034NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA054174
6 · The paper itself

Abstract

This review reflects the presentations and discussion at the 14th post-American Society of Hematology (ASH) International Workshop on Chronic Myeloproliferative Malignancies, which took place on the December 10 and 11, 2019, immediately after the 61st ASH Annual Meeting in Orlando, Florida. Rather than present a resume of the proceedings, we address some of the topical translational science research and clinically relevant topics in detail. We consider how recent studies using single-cell genomics and other molecular methods reveal novel aspects of hematopoiesis which in turn raise the possibility of new therapeutic approaches for patients with myeloproliferative neoplasms (MPNs). We discuss how alternative therapies could benefit patients with chronic myeloid leukemia who develop BCR-ABL1 mutant subclones following ABL1-tyrosine kinase inhibitor therapy. In MPNs, we focus on efforts beyond JAK-STAT and the merits of integrating activin receptor ligand traps, interferon-α, and allografting in the current treatment algorithm for patients with myelofibrosis.

Indexed as

Disease SusceptibilityAnemiaBiomarkersBiomarkers, TumorCombined Modality TherapyDisease ManagementDrug DevelopmentHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMolecular Diagnostic TechniquesMolecular Targeted TherapyMyeloproliferative DisordersPrognosisSingle-Cell AnalysisTranslational Research, BiomedicalTreatment OutcomeBiomarkersBiomarkers, TumorBCR-ABL1 mutantsgenomic risk scoresinterferon-alphaluspaterceptnon-JAK-STAT therapiessingle-cell genomics

Identifiers

PMID32592408
PMCPMC8895354
OpenAlexW3038008221

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.