Evidence map›Paper›PMID 32592396›Full record

ArticlePathogens and disease2020

Positive SARS-CoV-2 RNA recurs repeatedly in a case recovered from COVID-19: dynamic results from 108 days of follow-up.

Fang Liu, Zhao-Bin Cai, Jin-Song Huang, Wen-Yan Yu, Hai-Ying Niu, Yan Zhang, Dong-Ming Sui, Fei Wang, Li-Zhi Xue, Ai-Fang Xu

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Pathogens and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
0.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Is recurrence possible in coronavirus disease 2019 (COVID-19)? Case series and systematic review of literature.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Review
  8. CT Imaging Research Progress in COVID-19.Current medical imaging · 2022
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Recurrence of SARS-CoV-2 viral RNA in recovered COVID-19 patients: a narrative review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Fang LiuMedical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China.
Zhao-Bin CaiDepartment of Infectious Disease, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China.
Jin-Song HuangDepartment of Infectious Disease, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China.
Wen-Yan YuMedical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China.
Hai-Ying NiuMedical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China.
Yan ZhangMedical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China.
Dong-Ming SuiMedical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China.
Fei WangMedical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China.
Li-Zhi XueMedical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China.
Ai-Fang XuMedical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China.
Hangzhou Xixi hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The evidence of long-term clinical dynamic on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA re-positive case are less. We performed a 108 days follow-up on dynamic clinical presentations in a case, who hospitalized three times due to the positive recurrence of SARS-CoV-2 RNA after discharge, to understand the prognosis of the 2019-Coronavirus disease (COVID-19). In this case, positive SARS-CoV-2 recurred even after apparent recovery (normal CT imaging, no clinical symptoms, negative SARS-CoV-2 on stool sample and negative serum IgM test) from COVID-19, viral shedding duration lasted for 65 days, the time from symptom onset to disappearance was up to 95 days. Erythrocyte-associated indicators, liver function and serum lipid metabolism presented abnormal throughout during the observation period. Awareness of atypical presentations such as this one is important to prompt the improvement of the management of COVID-19.

Indexed as

Virus SheddingAdultAlanine TransaminaseAntiviral AgentsAspartate AminotransferasesBetacoronavirusBiomarkersCholesterol, HDLCoronavirus InfectionsCOVID-19gamma-GlutamyltransferaseHospitalizationHumansInterferon alpha-2LopinavirMaleAlanine TransaminaseAntiviral AgentsAspartate AminotransferasesBiomarkersCholesterol, HDLgamma-GlutamyltransferaseInterferon alpha-2LopinavirMethylprednisoloneRNA, Viralcoronavirus disease 2019erythrocytelong-term follow-uprecovered patientsSARS-CoV-2 re-positive

Identifiers

PMID32592396
PMCPMC7337794
OpenAlexW3037922331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.