Evidence map›Paper›PMID 32592359›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

Gastric Cancer in Aktobe Region of Western Kazakhstan from 2009 to 2018: Incidence Rates, Trends, and Five-Year Survival.

Saule K Balmagambetova, Yerbol Z Bekmukhambetov, Anar B Tulyaeva, Yerbolat M Iztleuov, Gaziza A Smagulova, Arip K Koyshybaev, Olzhas N Urazayev, Saganaj T Djussembekov, Valeriy V Begunov, Irakli Kokhreidze

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Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Saule K BalmagambetovaWest Kazakhstan Marat Ospanov Medical University, 68, Maresyev Street, Aktobe, Kazakhstan.ORCID 0000-0003-4080-5383
Yerbol Z BekmukhambetovWest Kazakhstan Marat Ospanov Medical University, 68, Maresyev Street, Aktobe, Kazakhstan.
Anar B TulyaevaWest Kazakhstan Marat Ospanov Medical University, 68, Maresyev Street, Aktobe, Kazakhstan.
Yerbolat M IztleuovWest Kazakhstan Marat Ospanov Medical University, 68, Maresyev Street, Aktobe, Kazakhstan.
Gaziza A SmagulovaWest Kazakhstan Marat Ospanov Medical University, 68, Maresyev Street, Aktobe, Kazakhstan.
Arip K KoyshybaevWest Kazakhstan Marat Ospanov Medical University, 68, Maresyev Street, Aktobe, Kazakhstan.
Olzhas N UrazayevWest Kazakhstan Marat Ospanov Medical University, 68, Maresyev Street, Aktobe, Kazakhstan.
Saganaj T DjussembekovWest Kazakhstan Marat Ospanov Medical University, 68, Maresyev Street, Aktobe, Kazakhstan.
Valeriy V BegunovWest Kazakhstan Marat Ospanov Medical University, 68, Maresyev Street, Aktobe, Kazakhstan.
Irakli KokhreidzeTbilisi State Medical University, 33, Vazha-Pshavela Ave., Tbilisi, Georgia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveto assess the current state of gastric cancer (GC) incidence and its five-year survival across Aktobe region of western Kazakhstan from 2009 to 2018 by presenting key indicators and analyzing the most significant features.

methodsRough incidence rates (per 100,000) and average annual percent changes (aAPCs) were estimated for each age group at diagnosis with respect to gender, ethnicity, residence, the disease stages, tumor subsite, and histology type using linear regression analysis, including the prognostic index for 2019-2020. Overall five-year survival rates were estimated by the Kaplan-Meier method.

resultsOverall GC incidence increased from 19.2 to 29.3, and averaged 25.8 (R2 0.65) with aAPC of 3.2%, with a potential to further rise (30.4 by 2020, p<0.001). Non-cardia location (17.8, p<0.001, aAPC 6.4%) and intestinal type of the tumor (17.0, p<0.001, aAPC 7.35%) were predominant. The observed overall five-year survival rate was 28.4% (95% CI 24.5;32.3) with a median survival time of 8.0 months (95% CI 6.6;9.4). Groups aged 40-49 and ≥70 had the lowest rates (24.4% and 22.1%, respectively, log-rank p 0.008), but the youngest individuals (18-39 years) showed the shortest median survival time, 5.0 months after diagnosis at the survival rate of 29.4%. Resectional surgery contributed significantly to the median survival time, 23.0 months vs. 6.0 in non-operated patients (log-rank p<0.001).

conclusionGC in Aktobe region was featured by growing incidence and unsatisfactory five-year survival rates. Indigenous males of 60-69 years old with intestinal histology type, as well as the youngest patients irrespective of their gender, ethnicity, and other characteristics were recognized as high risk groups. Besides, relatively high aAPC 5.1% in the youngest revealed their further expected vulnerability. Further research is suggested to focus on risk factors, including gene expression profiling, to find out an accessible preventive strategy.<br />.

Indexed as

AdolescentAdultAgedFemaleFollow-Up StudiesHumansIncidenceKazakhstanMaleMiddle AgedMortalityPrognosisRegistriesRetrospective StudiesRisk FactorsStomach Neoplasmsfive-year survivalGastric cancerIncidenceTrendswestern Kazakhstan

Identifiers

PMID32592359
PMCPMC7568899

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