Evidence map›Paper›PMID 32592358›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy.

Mauricio Pereira Maniglia, Anelise Russo, Patrícia Matos Biselli-Chicote, Juliana Garcia De Oliveira-Cucolo, Gabriela Helena Rodrigues-Fleming, José Victor -Maniglia, Érika Cristina Pavarino, Eny Maria Goloni-Bertollo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Gene polymorphisms and prognosis of head and neck squamous cell carcinoma: a systematic review.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
    Review
  4. Gene polymorphisms and risk of head and neck squamous cell carcinoma: a systematic review.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
    Review
  5. The Association of Polymorphisms inOxidative medicine and cellular longevity · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mauricio Pereira ManigliaDepartment of Molecular Biological, Genetics and Molecular Biology Research Unit - UPGEM, Faculty of Medicine of São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil.
Anelise RussoDepartment of Molecular Biological, Genetics and Molecular Biology Research Unit - UPGEM, Faculty of Medicine of São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil.
Patrícia Matos Biselli-ChicoteDepartment of Molecular Biological, Genetics and Molecular Biology Research Unit - UPGEM, Faculty of Medicine of São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil.
Juliana Garcia De Oliveira-CucoloDepartment of Molecular Biological, Genetics and Molecular Biology Research Unit - UPGEM, Faculty of Medicine of São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil.
Gabriela Helena Rodrigues-FlemingDepartment of Molecular Biological, Genetics and Molecular Biology Research Unit - UPGEM, Faculty of Medicine of São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil.
José Victor -ManigliaDepartment of Otolaryngology and Head and Neck Surgery, Sao Jose do Rio Preto Medical School, São José do Rio Preto, São Paulo, Brazil.
Érika Cristina PavarinoDepartment of Molecular Biological, Genetics and Molecular Biology Research Unit - UPGEM, Faculty of Medicine of São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil.ORCID 0000000309590695
Eny Maria Goloni-BertolloDepartment of Molecular Biological, Genetics and Molecular Biology Research Unit - UPGEM, Faculty of Medicine of São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil.
Faculdade de Medicina de São José do Rio Preto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThe Glutathione S-transferases (GSTs) are important carcinogen-metabolizing enzymes. Polymorphisms involved in these enzymes can modulate the development and treatment of head and neck cancer. To investigate the association of GSTs polymorphisms with head and neck cancer and risk factors, clinical-pathological features, and survival time of the patients treated with chemotherapy and/or radiotherapy.

methodsThe GST gene polymorphisms were evaluated in 197 cases and 514 controls by PCR-RFLP-Polymerase Chain Reaction Restriction Fragment Length Polymorphism.

resultsThe GSTP-313 was associated with a decreased risk for HNSCC (p=0.050). The GSTP1 haplotype analysis revealed a higher frequency of the AC and AT haplotypes in the case group than in the control group (p=0.013 and p=0.019, respectively), and the opposite for G-C haplotype (p = 0.015). Yet, the different combinations between the genotypes were associated with an increased risk of cancer. The study showed no association between the polymorphisms and primary tumor site, clinical-pathological characteristics, treatment (chemotherapy and/or radiotherapy) and survival time of the patients.

conclusionThe GST polymorphisms combination showed an increased risk for carcinogenesis, and studies with larger casuistry can contribute to the clarification of the role in individual patient differences for the response to chemotherapy and/or radiotherapy and identify biomarkers of susceptibility.

Indexed as

Polymorphism, GeneticAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorChemoradiotherapyCisplatinFemaleFluorouracilFollow-Up StudiesGenetic Predisposition to DiseaseGlutathione S-Transferase piHaplotypesHead and Neck NeoplasmsHumansBiomarkers, TumorCisplatinFluorouracilGlutathione S-Transferase piGSTP1 protein, humanMethotrexateChemotherapy AgentsGenetic polymorphismGlutathione Transferasehead and neck neoplasmsradiotherapy

Identifiers

PMID32592358
PMCPMC7568907
OpenAlexW3038061042

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.