Evidence map›Paper›PMID 32592116›Full record

ArticleMolecular biology reports2020

Evolutionarily conserved and testis-specific gene, 4930524B15Rik, is not essential for mouse spermatogenesis and fertility.

Ranjha Khan, Jingwei Ye, Ayesha Yousaf, Wasim Shah, Ayesha Aftab, Basit Shah, Qamar Zaman, Muhammad Zubair, Qinghua Shi, Xiaohua Jiang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Inactivation of testis-specific gene C4orf46 is dispensable for spermatogenesis and fertility in mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 2021
    Article
  2. Article
  3. Article
  4. Novel Loss-of-Function Mutations inFrontiers in endocrinology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Ranjha KhanThe First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences At Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.
Jingwei YeThe First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences At Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.
Ayesha YousafThe First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences At Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.
Wasim ShahThe First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences At Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.
Ayesha AftabDepartment of Biological Sciences, International Islamic University, Sector H10, Islamabad, 44000, Pakistan.
Basit ShahThe First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences At Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.
Qamar ZamanThe First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences At Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.
Muhammad ZubairThe First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences At Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.
Qinghua ShiThe First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences At Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China. qshi@ustc.edu.cn.
Xiaohua JiangThe First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences At Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China. biojxh@ustc.edu.cn.ORCID http://orcid.org/0000-0002-5682-6827
University of Science and Technology of China · CNInternational Islamic University, Islamabad · PK

Funding

Fundamental Research Funds for the Central Universities YD2070002006Major Program of Development Foundation of Hefei Centre for Physical Science and Technology 2018ZYFX005National Key Research and Developmental Program of China 2016YFC1000600 and 2018YFC1004700National Natural Science Foundation of China 31871514National Natural Science Foundation of China 31890780 and 31630050the Strategic Priority Research Program of the Chinese Academy of Sciences XDB19000000
6 · The paper itself

Abstract

Thousands of genes are involved in spermatogenesis, however, the functional roles of most these genes for male fertility remain to be discovered. This research focused to explore the function of evolutionarily conserved and testis-specific expressed gene 4930524B15Rik, which is known as C5orf47 in human. We generated 4930524B15Rik knockout mice by CRISPR/Cas9 technology and found 4930524B15Rik

Indexed as

Genetic LociSpermatogenesisAnimalsConserved SequenceEvolution, MolecularGene DeletionInfertility, MaleMaleMiceTestis4930524B15RikC5orf47FertilitySpermatogenesisTestis-specific gene

Identifiers

PMID32592116
OpenAlexW3037804536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.