Evidence map›Paper›PMID 32591989›Full record

ArticleMedical & biological engineering & computing2020

An in vitro model of temporal enhancement of epithelium barrier permeability by low-energy shock waves without contrast agents.

Yuki Monden, Akira Tsukamoto, Takashi Ushida, Etsuko Kobayashi, Keiichi Nakagawa, Ichiro Sakuma

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Article in Medical & biological engineering & computing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuki MondenDepartment of Precision Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.
Akira TsukamotoDepartment of Applied Physics, National Defense Academy, Kanagawa, 239-8686, Japan. tsuka@nda.ac.jp.
Takashi UshidaDepartment of Mechanical Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.
Etsuko KobayashiDepartment of Precision Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.
Keiichi NakagawaDepartment of Precision Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.
Ichiro SakumaDepartment of Precision Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.
The University of Tokyo · JPNational Defense Academy of Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the commonly used techniques for drug delivery is to temporarily increase the permeability of tissue barriers. Acoustic energies such as ultrasound and shock waves are known to modulate tissue permeability. Recently, it was found that shock waves modulate the blood-brain barrier in the rat brain without injection of contrast agents such as microbubbles. This finding implies that modulation of other tissue barriers by shock wave exposure without contrast agents may be possible. To examine whether the modulation is also possible with other tissue barriers, we here investigated whether shock waves would modulate an in vitro tissue barrier model consisting of epithelial cells cultured on culture inserts. The permeability of the epithelium sheets evaluated by trans-epithelial electrical resistance (TEER) was increased following shock waves at a peak pressure of 11 MPa. The increased permeability recovered within 2 h. This enhancement was realized with one-shot low-energy shock waves having an acoustic energy of 0.013 mJ/mm

Indexed as

Drug Delivery SystemsPermeabilitySoundAnimalsBiomedical EngineeringDogsElectric ImpedanceEpitheliumHumansIn Vitro TechniquesMadin Darby Canine Kidney CellsRatsEpithelium barrierMinimum peak pressureShock wavesTemporary enhancementTrans-epithelial electrical resistance

Identifiers

PMID32591989
OpenAlexW3037188292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.