Evidence map›Paper›PMID 32591901›Full record

Trial reportWorld journal of urology2021

Intranasal ketamine versus intravenous morphine for pain management in patients with renal colic: a double-blind, randomized, controlled trial.

Mahboub Pouraghaei, Payman Moharamzadeh, Seyed Pouya Paknezhad, Zahra Vand Rajabpour, Hassan Soleimanpour

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

  • Commented on by
    2022
5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mahboub PouraghaeiEmergency Medicine Research Team, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID http://orcid.org/0000-0002-8421-6110
Payman MoharamzadehEmergency Medicine Research Team, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID http://orcid.org/0000-0002-6960-9311
Seyed Pouya PaknezhadEmergency Medicine Research Team, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-0486-5525
Zahra Vand RajabpourStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID http://orcid.org/0000-0002-2025-0301
Hassan SoleimanpourResearch Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. soleimanpourh@tbzmed.ac.ir.ORCID http://orcid.org/0000-0002-1311-4096
Tabriz University of Medical Sciences · IR

Funding

Tabriz University of Medical Sciences IR.TBZMED.REC.1398.006.
6 · The paper itself

Abstract

backgroundUrinary stones are a common urologic problem that can be manifested as an intense pain, known as renal colic. Pain control is an important intervention for the emergency treatment of renal colic patients. Intranasal ketamine can form a crucial part of such interventions by offering a new route for a widely-used analgesic drug.

methodsIn a double-blind, randomized, clinical trial, adults with renal colic admitted to a tertiary hospital emergency department were examined. The intervention group received 1 mg/kg intranasal (IN) ketamine and 1 ml of saline as a placebo. The control group received 0.1 mg/kg intravenous (IV) morphine and four puffs of saline as the placebo. The pain score was measured on the Numerical Rating Scale (NRS) 0, 15, 30 and 60 min after the drug administration.

resultsA total of 184 patients enrolled in this study in two parallel groups. The two groups did not differ significantly in terms of pain intensity at the time of their referral (P = 0.489), 15 min post-dose (P = 0.204), 30 min post-dose (P = 0.978) and 60 min post-dose (P = 0.648).

conclusionIN ketamine is as effective as IV morphine for pain control in renal colic patients. No remarkable side-effects were observed for IN ketamine use in these patients.

Indexed as

Administration, IntranasalAdultDouble-Blind MethodHumansInjections, IntravenousKetamineMiddle AgedMorphinePain MeasurementRenal ColicYoung AdultKetamineMorphineKetamineKidney stonesMorphine

Identifiers

PMID32591901
OpenAlexW3037357782

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.