Evidence map›Paper›PMID 32591868›Full record

SynthesisClinical oral investigations2020

Use of platelet-rich fibrin for the treatment of gingival recessions: a systematic review and meta-analysis.

Richard J Miron, Vittorio Moraschini, Massimo Del Fabbro, Adriano Piattelli, Masako Fujioka-Kobayashi, Yufeng Zhang, Nikola Saulacic, Benoit Schaller, Tomoyuki Kawase, Raluca Cosgarea and 14 more

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05591326 (The Effect of Using Injectable Platelet-rich Fibrin with Microneedling Technique on Creeping Attachment), which is not on this map. Cited by 63 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05591326 naenrolling by invitationnot on this mapstarted 2021, after this paper: background citation

The Effect of Using Injectable Platelet-rich Fibrin with Microneedling Technique on Creeping Attachment

TypeinterventionalSponsorBerceste GulerRan2021 to 2025Enrolled50ConditionsGingival Recession, Gingival Recession, LocalizedArmsi-PRF application procedure
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Richard J MironDepartment of Periodontology, University of Bern, Bern, Switzerland. richard.miron@zmk.unibe.ch.ORCID http://orcid.org/0000-0003-3290-3418
Vittorio MoraschiniDepartment of Periodontology, Dental Research Division, School of Dentistry, Veiga de Almeida University, Rio de Janeiro, Brazil.
Massimo Del FabbroDepartment of Biomedical, Surgical, and Dental Sciences, University of Milan, Milan, Italy.
Adriano PiattelliDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy.
Masako Fujioka-KobayashiDepartment of Cranio-Maxillofacial Surgery, University of Bern, Bern, Switzerland.
Yufeng ZhangDepartment of Oral Implantology, University of Wuhan, Wuhan, China.
Nikola SaulacicDepartment of Cranio-Maxillofacial Surgery, University of Bern, Bern, Switzerland.
Benoit SchallerDepartment of Cranio-Maxillofacial Surgery, University of Bern, Bern, Switzerland.
Tomoyuki KawaseDivision of Oral Bioengineering, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan.
Raluca CosgareaDepartment of Prosthetic Dentistry, University Iuliu Hatieganu, Cluj-Napoca, Romania.
Soren JepsenDepartment of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.
Delia TuttleCanyon Lake Dental Office, Lake Elsinore, CA, USA.
Mark BisharaWest Bowmanville Family Dental, Bowmanville, Ontario, Canada.
Luigi Canullo, Rome, Italy.
Meizi EliezerDepartment of Periodontology, University of Bern, Bern, Switzerland.
Andreas StavropoulosDepartment of Periodontology, University of Geneva, Geneva, Switzerland.
Yoshinori ShirakataDepartment of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Alexandra StähliDepartment of Periodontology, University of Bern, Bern, Switzerland.
Reinhard GruberDepartment of Oral Biology, University of Vienna, Vienna, Austria.
Ondine LucaciuDepartment of Prosthetic Dentistry, University Iuliu Hatieganu, Cluj-Napoca, Romania.
Sofia ArocaDepartment of Periodontology, University of Bern, Bern, Switzerland.
Herbert DeppeDepartment of Oral and Maxillofacial Surgery, Klinikum rechts der Isar der TUM, Munich, Germany.
Hom-Lay WangDepartment of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI, USA.
Anton SculeanDepartment of Periodontology, University of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this systematic review and meta-analysis was to compare the use of platelet-rich fibrin (PRF) with other commonly utilized treatment modalities for root coverage procedures. MATERIALS AND

methodsThe eligibility criteria comprised randomized controlled trials (RCTs) comparing the performance of PRF with that of other modalities in the treatment of Miller class I or II (Cairo RT I) gingival recessions. Studies were classified into 5 categories as follows: (1) coronally advanced flap (CAF) alone vs CAF/PRF, (2) CAF/connective tissue graft (CAF/CTG) vs CAF/PRF, (3) CAF/enamel matrix derivative (CAF/EMD) vs CAF/PRF, (4) CAF/amnion membrane (CAF/AM) vs CAF/PRF, and (5) CAF/CTG vs CAF/CTG/PRF. Studies were evaluated for percentage of relative root coverage (rRC; primary outcome), clinical attachment level (CAL), keratinized mucosa width (KMW), and probing depth (PD) (secondary outcomes).

resultsFrom 976 articles identified, 17 RCTs were included. The use of PRF statistically significantly increased rRC and CAL compared with CAF alone. No change in KMW or reduction in PD was reported. Compared with PRF, CTG resulted in statistically significantly better KMW and RC. No statistically significant differences were reported between the CAF/PRF and CAF/EMD groups or between the CAF/PRF and CAF/AM groups for any of the investigated parameters.

conclusionsThe use of CAF/PRF improved rRC and CAL compared with the use of CAF alone. While similar outcomes were observed between CAF/PRF and CAF/CTG for CAL and PD change, the latter group led to statistically significantly better outcomes in terms of rRC and KTW. In summary, the use of PRF in conjunction with CAF may represent a valid treatment modality for gingival recessions exhibiting adequate baseline KMW. CLINICAL RELEVANCE: The data indicate that the use of PRF in conjunction with CAF statistically significantly improves rRC when compared with CAF alone but did not improve KMW. Therefore, in cases with limited baseline KMW, the use of CTG may be preferred over PRF.

Indexed as

Gingival RecessionConnective TissueGingivaHumansPlatelet-Rich FibrinSurgical FlapsTooth RootTreatment OutcomeGingival recessionL-PRFPeriodontal plastic surgeryPlatelet-rich fibrin

Identifiers

PMID32591868

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.