ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2021
Renal function decline in older men and women with advanced chronic kidney disease-results from the EQUAL study.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Cardiovascular Disease in CKD: Ethnic and Regional Differences in Risk and Phenotype.Clinical journal of the American Society of Nephrology : CJASN · 2026Review
- ERRγ deletion in podocytes accelerates aging related kidney disease.bioRxiv : the preprint server for biology · 2026Article
- Article
- Acute kidney injury does not explain sex differences in kidney replacement therapy initiation or death amongst individuals with chronic kidney disease reported to the UK Renal Registry.Clinical kidney journal · 2025Article
- Prospects for lithium treated patients with severe renal impairment.International journal of bipolar disorders · 2025Article
- Association of Geriatric Nutritional Risk Index With Cardiovascular and All-Cause Mortality Among US Elderly Adults With Diabetic Nephropathy.Journal of diabetes research · 2025Article
- Sex-specific differences in the efficacy of renal denervation in patients with resistant hypertension depending on visceral obesity and kidney function.Frontiers in cardiovascular medicine · 2025Article
- The association of sex differences in ambulatory blood pressure with cardiovascular events and mortality in dialysis patients.Journal of human hypertension · 2024Observational
- The safety of a low-protein diet in older adults with advanced chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Observational
- Approximation of Glomerular Filtration Rate after 1 Year Using Annual Medical Examination Data.Journal of clinical medicine · 2024Article
- Sex disparities in mortality and cardiovascular outcomes in chronic kidney disease.Clinical kidney journal · 2024Review
- Differences in the epidemiology, management and outcomes of kidney disease in men and women.Nature reviews. Nephrology · 2024Review
- Age and estimated glomerular filtration rate in Chinese older adults: a cohort study from 2014 to 2020.Frontiers in public health · 2024Observational
- Incidence of hospital-acquired acute kidney injury and trajectories of glomerular filtration rate in older adults.BMC nephrology · 2023Article
- Risk Factors for Incident CKD in Black and White Americans: The REGARDS Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023Observational
- Ageing meets kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Role of sex hormones in diabetic nephropathy.Frontiers in endocrinology · 2023Review
- Ageing meets kidney disease.Clinical kidney journal · 2022Article
- 15-year-change of phenotype and prognosis in non-dialysis CKD patients referred to a nephrology clinic.International urology and nephrology · 2022Observational
- Health-Related Quality-of-Life Trajectories over Time in Older Men and Women with Advanced Chronic Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2022Observational
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Authors and funding
11 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionUnderstanding the mechanisms underlying the differences in renal decline between men and women may improve sex-specific clinical monitoring and management. To this end, we aimed to compare the slope of renal function decline in older men and women in chronic kidney disease (CKD) Stages 4 and 5, taking into account informative censoring related to the sex-specific risks of mortality and dialysis initiation.
methodsThe European QUALity Study on treatment in advanced CKD (EQUAL) study is an observational prospective cohort study in Stages 4 and 5 CKD patients ≥65 years not on dialysis. Data on clinical and demographic patient characteristics were collected between April 2012 and December 2018. Estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration equation. eGFR trajectory by sex was modelled using linear mixed models, and joint models were applied to deal with informative censoring.
resultsWe included 7801 eGFR measurements in 1682 patients over a total of 2911 years of follow-up. Renal function declined by 14.0% [95% confidence interval (CI) 12.9-15.1%] on average each year. Renal function declined faster in men (16.2%/year, 95% CI 15.9-17.1%) compared with women (9.6%/year, 95% CI 6.3-12.1%), which remained largely unchanged after accounting for various mediators and for informative censoring due to mortality and dialysis initiation. Diabetes was identified as an important determinant of renal decline specifically in women.
conclusionIn conclusion, renal function declines faster in men compared with women, which remained similar after adjustment for mediators and despite a higher risk of informative censoring in men. We demonstrate a disproportional negative impact of diabetes specifically in women.
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