ArticleCerebral cortex (New York, N.Y. : 1991)2020
White Matter Development from Birth to 6 Years of Age: A Longitudinal Study.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- Trial
- Nucleus Accumbens and Ventral Tegmental Area Functional Connectivity as a Marker of Reward Sensitivity in Infancy.Developmental science · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Dynamics of infant white matter maturation from birth to 6 months.Communications biology · 2026Article
- Microstructure of white matter fiber tracts in infants with positional plagiocephaly.Pediatric radiology · 2026Article
- Maternal depression with and without a history of childhood maltreatment and newborn white matter microstructure.Psychological medicine · 2026Article
- Nutrition in early life interacts with genetic risk to influence preadult behaviour in the Raine Study.Communications medicine · 2026Article
- Hierarchical maturation of structural brain connectomes from birth to childhood.Nature communications · 2026Article
- Long-term associations between perinatal factors and white matter microstructure at 8-10 years.Frontiers in human neuroscience · 2026Article
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Sex- and Age-Specific Characteristics of Running Performance Assessed by OptoJump in Pre-School Children Aged 3 to 6 Years.Children (Basel, Switzerland) · 2025Article
- Early but discontinued exposure to a language exerts lasting effects on white matter architecture in the brain.Communications biology · 2025Article
- Article
- White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies.bioRxiv : the preprint server for biology · 2025Article
- Sex differences in maturational timing of amygdala and prefrontal cortex volumes and white matter tract microstructure.Developmental cognitive neuroscience · 2025Article
- Volume changes in white matter pathways from infancy to early adulthood measured using diffusion tensor based morphometry.Frontiers in neurology · 2025Article
- The importance of sleep for the developing brain.Current sleep medicine reports · 2024Article
- Gray matter based spatial statistics framework in the 1-month brain: insights into gray matter microstructure in infancy.Brain structure & function · 2024Article
- Functional and structural maturation of auditory cortex from 2 months to 2 years old.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- White matter microstructure and functional connectivity in the brains of infants with Turner syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Human white matter development in the first years of life is rapid, setting the foundation for later development. Microstructural properties of white matter are linked to many behavioral and psychiatric outcomes; however, little is known about when in development individual differences in white matter microstructure are established. The aim of the current study is to characterize longitudinal development of white matter microstructure from birth through 6 years to determine when in development individual differences are established. Two hundred and twenty-four children underwent diffusion-weighted imaging after birth and at 1, 2, 4, and 6 years. Diffusion tensor imaging data were computed for 20 white matter tracts (9 left-right corresponding tracts and 2 commissural tracts), with tract-based measures of fractional anisotropy and axial and radial diffusivity. Microstructural maturation between birth and 1 year are much greater than subsequent changes. Further, by 1 year, individual differences in tract average values are consistently predictive of the respective 6-year values, explaining, on average, 40% of the variance in 6-year microstructure. Results provide further evidence of the importance of the first year of life with regard to white matter development, with potential implications for informing early intervention efforts that target specific sensitive periods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.