SynthesisBritish dental journal2020
Antibiotic prophylaxis for implant placement: a systematic review of effects on reduction of implant failure.
Synthesis in British dental journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Is routine antibiotic prophylaxis warranted in dental implant surgery to prevent early implant failure? - a systematic review.BMC oral health · 2024Pooled it
- Is clindamycin effective in preventing infectious complications after oral surgery? Systematic review and meta-analysis of randomized controlled trials.Clinical oral investigations · 2022Pooled it
- Dental Implants in People with Osteogenesis Imperfecta: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Early versus conventional loading for fully guided immediate implant placement in molar sites: a randomized controlled clinical study.International journal of implant dentistry · 2025Trial
- The effect of preoperative clindamycin in reducing early oral implant failure: a randomised placebo-controlled clinical trial.Clinical oral investigations · 2023Trial
- A 3-year prospective randomized clinical trial of alveolar bone crest response and clinical parameters through 1, 2, and 3 years of clinical function of implants placed 4 months after alveolar ridge preservation using two different allogeneic bone-grafting materials.International journal of implant dentistry · 2022Trial
- Do postoperative antibiotics influence one-year peri-implant crestal bone remodelling and morbidity? A double-blinded randomized clinical trial.Clinical oral implants research · 2021Trial
- Patterns of Surgical Prophylaxis Prescribing for Dentoalveolar Procedures in Australian Hospitals: 2016-2022.Australian dental journal · 2026Article
- Dental Antibiotic Prescribing Practices and Antimicrobial Resistance Knowledge in Singapore.International dental journal · 2026Article
- Liver Abscess Caused byJournal of clinical medicine · 2025Article
- Retrospective Evaluation of Peri-Implant Maintenance in Patients With Implant-Supported Fixed Prostheses.International journal of dentistry · 2025Article
- Patient Centricity-An Empirical Research on Titanium Dental Implants and Their Adverse Effects on Health Condition.Healthcare (Basel, Switzerland) · 2024Article
- Article
- Antibiotic Prescription for Treatment and Prevention of Odontogenic Infections: A Cross-Sectional Survey of Lithuanian Dentists.Medicina (Kaunas, Lithuania) · 2024Article
- Antibiotic prescribing patterns among dentists in Italy and Albania: A comparative questionnaire analysis.Heliyon · 2024Article
- The Impact of Systemic Drug Therapies (Bisphosphonates and Immunosuppressants) on Dental Implant Success: A Clinical Review.Galen medical journal · 2024Review
- Histatin 1-modified SIS hydrogels enhance the sealing of peri-implant mucosa to prevent peri-implantitis.iScience · 2023Article
- Osteonecrosis of the jaws in patients under osteoporosis treatment: a nine-year experience report.Archives of endocrinology and metabolism · 2023Article
- Static Computer-Aided Implant Surgery: An Ally Against Bacterial Antimicrobial Resistance?International dental journal · 2023Article
- Comparative Efficacy of Different Amoxicillin Dosing Regimens in Preventing Early Implant Failure-A Systematic Review with Network Meta-Analysis.Antibiotics (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Despite excellent reviews in the past several years, the use of antibiotics as prophylaxis for implant placement remains controversial.Aim To assess the literature on the efficacy of prophylactic antibiotics prescribed prior to and immediately following implant surgery (PIFS).Outcomes Whether administration of antibiotics reduced implant failure and post-operative complications.Design Databases searched were PubMed and Medline via Ovid (1946 to February 2018), Cochrane Library (Wiley) and Google Scholar.Materials and methods Quality assessment, meta-analysis with a forest plot and incorporated assessment of heterogeneity. A two-tailed paired t-test was performed, analysing differences in mean failure rates between groups.Results Fourteen publications were collected; 5,334 implants were placed with pre-operative antibiotics, 82 implants with antibiotics PIFS and 3,862 placed with no antibiotics. The overall risk ratio (RR) was 0.47 (95% CI 0.39-0.58), with the implant failure rates significantly affected by pre-operative intervention (Z = 7.00, P <0.00001). The number needed to treat (NNT) was 35 (95% CI 26.3-48.2). The difference between mean failure rates was statistically significant (P = 0.0335).Conclusion Administering prophylactic antibiotics reduced the risk of implant failures. Further investigations are recommended to establish a standardised protocol for the proper use of antibiotic regimen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.