ArticleScientific reports2020
Life Course Trajectories of Maternal Cardiovascular Risk Factors according to Offspring Birthweight: The HUNT Study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study.BMC medicine · 2024Pooled it
- Reproductive risk factors and prevalence of cardiovascular-kidney-metabolic syndrome among young women.American journal of preventive cardiology · 2026Article
- Life course trajectories of maternal cardiovascular disease risk factors by obstetric history: a UK cohort study using electronic health records.BMC medicine · 2025Article
- Update on sex specific risk factors in cardiovascular disease.Frontiers in cardiovascular medicine · 2024Review
- Placental syndromes and long-term risk of hypertension.Journal of human hypertension · 2023Review
- Pregnancy and Reproductive Risk Factors for Cardiovascular Disease in Women.Circulation research · 2022Review
- Ten-Year Cardiovascular Disease Risk Trajectories by Obstetric History: A Longitudinal Study in the Norwegian HUNT Study.Journal of the American Heart Association · 2022Article
- Does gestational diabetes increase the risk of maternal kidney disease? A Swedish national cohort study.PloS one · 2022Article
- The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study.Scientific reports · 2021Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Women with small or large for gestational age offspring are at increased risk of cardiovascular disease later in life. How their cardiovascular risk factors develop across the life course is incompletely known. We linked data from the population-based HUNT Study (1984-2008) and the Medical Birth Registry of Norway (1967-2012) for 22,487 women. Mixed effect models were used to compare cardiovascular risk factor trajectories for women according to first offspring birthweight for gestational age. Women with small for gestational age (SGA) offspring had 1-2 mmHg higher systolic and diastolic blood pressure across the life course, but lower measures of adiposity, compared to women with offspring who were appropriate for gestational age (AGA). In contrast, women with large for gestational age (LGA) offspring had higher measures of adiposity, ~0.1 mmol/l higher non-HDL cholesterol and triglycerides and 0.2 mmol/l higher non-fasting glucose, compared with mothers of AGA offspring. These differences were broadly stable from prior to first pregnancy until 60 years of age. Our findings point to different cardiovascular risk profiles in mothers of SGA versus LGA offspring, where giving birth to SGA offspring might primarily reflect adverse maternal vascular health whereas LGA offspring might reflect the mother's metabolic health.
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