ArticleNature communications2020
Closed-loop atomic force microscopy-infrared spectroscopic imaging for nanoscale molecular characterization.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Unravelling emergence of chirality in click-chemistry polymers down to the single-chain level.Nature communications · 2025Article
- Force Volume Atomic Force Microscopy-Infrared for Simultaneous Nanoscale Chemical and Mechanical Spectromicroscopy.ACS nano · 2025Article
- An analytical model of label-free nanoscale chemical imaging reveals avenues toward improved spatial resolution and sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- An end-to-end approach for single-cell infrared absorption spectroscopy of bacterial inclusion bodies: from AFM-IR measurement to data interpretation of large sample sets.Journal of nanobiotechnology · 2024Article
- Modeling the Thermoelastic Sample Response for Subdiffraction Infrared Spectroscopic Imaging.Chemical & biomedical imaging · 2024Article
- Structural characterization of amyloid aggregates with spatially resolved infrared spectroscopy.Methods in enzymology · 2024Article
- AFM-IR for Nanoscale Chemical Characterization in Life Sciences: Recent Developments and Future Directions.ACS measurement science au · 2023Review
- Infrared spectroscopic laser scanning confocal microscopy for whole-slide chemical imaging.Nature communications · 2023Article
- High-Fidelity Micro- and Nano-Scale Infrared Spectroscopic Imaging.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2023Article
- Digital Histopathology by Infrared Spectroscopic Imaging.Annual review of analytical chemistry (Palo Alto, Calif.) · 2023Review
- Chemical imaging of cellular ultrastructure by null-deflection infrared spectroscopic measurements.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nanoscale Infrared Spectroscopy Identifies Structural Heterogeneity in Individual Amyloid Fibrils and Prefibrillar Aggregates.The journal of physical chemistry. B · 2022Article
- Non-von Neumann multi-input spike signal processing enabled by an artificial synaptic multiplexer.Science advances · 2022Article
- Structurally Distinct Polymorphs of Tau Aggregates Revealed by Nanoscale Infrared Spectroscopy.The journal of physical chemistry letters · 2021Article
- Design Considerations for Discrete Frequency Infrared Microscopy Systems.Applied spectroscopy · 2021Article
- Ultra-thin self-healing vitrimer coatings for durable hydrophobicity.Nature communications · 2021Article
- Recent Progress on the Characterization of Cellulose Nanomaterials by Nanoscale Infrared Spectroscopy.Nanomaterials (Basel, Switzerland) · 2021Review
- Analysis of Fixed and Live Single Cells Using Optical Photothermal Infrared with Concomitant Raman Spectroscopy.Analytical chemistry · 2021Article
- Substrate-mediated hyperbolic phonon polaritons in MoONanophotonics (Berlin, Germany) · 2021Article
- Overcoming thermo-optical dynamics in broadband nanophotonic sensing.Microsystems & nanoengineering · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Atomic force microscopy-infrared (AFM-IR) spectroscopic imaging offers non-perturbative, molecular contrast for nanoscale characterization. The need to mitigate measurement artifacts and enhance sensitivity, however, requires narrowly-defined and strict sample preparation protocols. This limits reliable and facile characterization; for example, when using common substrates such as Silicon or glass. Here, we demonstrate a closed-loop (CL) piezo controller design for responsivity-corrected AFM-IR imaging. Instead of the usual mode of recording cantilever deflection driven by sample expansion, the principle of our approach is to maintain a zero amplitude harmonic cantilever deflection by CL control of a subsample piezo. We show that the piezo voltage used to maintain a null deflection provides a reliable measure of the local IR absorption with significantly reduced noise. A complete analytical description of the CL operation and characterization of the controller for achieving robust performance are presented. Accurate measurement of IR absorption of nanothin PMMA films on glass and Silicon validates the robust capability of CL AFM-IR in routine mapping of nanoscale molecular information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.