Evidence map›Paper›PMID 32591436›Full record

ReviewPediatrics2020

Ethical and Public Health Implications of Targeted Screening for Congenital Cytomegalovirus.

Ladawna L Gievers, Alison Volpe Holmes, Jaspreet Loyal, Ilse A Larson, Carlos R Oliveira, Erik H Waldman, Sheevaun Khaki

Open access · greenAbstract readReview
In one paragraph

Review in Pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Pharmacoepidemiology of Antiviral Treatment for Congenital Cytomegalovirus in Neonates.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ladawna L GieversDepartment of Pediatrics, Oregon Health and Science University, Portland, Oregon; gievers@ohsu.edu.
Alison Volpe HolmesDepartment of Pediatrics, Geisel School of Medicine, Dartmouth College and Children's Hospital at Dartmouth-Hitchcock, Lebanon, New Hampshire; and.
Jaspreet LoyalDepartments of Pediatrics and.
Ilse A LarsonDepartment of Pediatrics, Oregon Health and Science University, Portland, Oregon.
Carlos R OliveiraDepartments of Pediatrics and.
Erik H WaldmanHead and Neck Surgery, Section of Otolaryngology and.
Sheevaun KhakiDepartment of Pediatrics, Oregon Health and Science University, Portland, Oregon.
Oregon Health & Science University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
NCATS NIH HHS KL2 TR001862NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Congenital cytomegalovirus (cCMV) is the most common congenital infection and is associated with sensorineural hearing loss, developmental delays, and visual impairment. The clinical presentation of cCMV is variable, and the majority (80%-90%) of newborns will never manifest any clinical symptoms. Given the clinical heterogeneity of cCMV infection, it is challenging to identify which newborns may benefit from testing. Recently, certain states have implemented a targeted screening program in which newborns who fail the newborn hearing screen are tested for cCMV. Clinicians and legislative bodies have been propelled into debates about the ethical and moral permissibility of a targeted cCMV screening approach. Those who oppose this screening approach describe undue burden on patients, families, and the health care system because the majority of newborns who fail the newborn hearing screen and have cCMV will not go on to have any sequelae related to cCMV, including hearing loss. However, those who support this screening approach cite the importance of early detection and ongoing surveillance for hearing loss and developmental delays in this high-risk group of newborns. This debate will be considered by experts in the field.

Indexed as

Early DiagnosisCytomegalovirusCytomegalovirus InfectionsHearing Loss, SensorineuralHearing TestsHumansInfant, NewbornNeonatal Screening

Identifiers

PMID32591436
PMCPMC8171256
OpenAlexW3037276953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.