ArticleJournal of medical genetics2021
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.
Article in Journal of medical genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Genetically adjusted PSA levels for prostate cancer screening.Nature medicine · 2023Pooled it
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- From Anatomy to Innovation: Embedding Patient-Centered Design in Medical Education.JMIR medical education · 2026Article
- Bilateral Patellar Tendon Rupture in a 64-Year-Old Man: Possible Interaction of Inhaled Corticosteroids, Age and Mechanical Stress.Case reports in orthopedics · 2026Article
- Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer.NPJ genomic medicine · 2025Article
- Genome-Wide Study of the UK Biobank Highlights the Importance of the Homeobox-C Gene Cluster in Hip Fracture Risk.Geriatric orthopaedic surgery & rehabilitation · 2025Article
- New role of fat-free mass in cancer risk linked with genetic predisposition.Scientific reports · 2024Article
- Exploring the frequency of a TP53 polyadenylation signal variant in tumor DNA from patients diagnosed with lung adenocarcinomas, sarcomas and uterine leiomyomas.Genetics and molecular biology · 2024Article
- Diversity of thought: public perceptions of genetic testing across ethnic groups in the UK.Journal of human genetics · 2024Article
- Obesity: a perfect storm for carcinogenesis.Cancer metastasis reviews · 2022Review
- GSEA-SDBE: A gene selection method for breast cancer classification based on GSEA and analyzing differences in performance metrics.PloS one · 2022Article
- Height and Risk of Vitiligo: A Nationwide Cohort Study.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHeight and other anthropometric measures are consistently found to associate with differential cancer risk. However, both genetic and mechanistic insights into these epidemiological associations are notably lacking. Conversely, inherited genetic variants in tumour suppressors and oncogenes increase cancer risk, but little is known about their influence on anthropometric traits.
methodsBy integrating inherited and somatic cancer genetic data from the Genome-Wide Association Study Catalog, expression Quantitative Trait Loci databases and the Cancer Gene Census, we identify SNPs that associate with different cancer types and differential gene expression in at least one tissue type, and explore the potential pleiotropic associations of these SNPs with anthropometric traits through SNP-wise association in a cohort of 500,000 individuals.
resultsWe identify three regulatory SNPs for three important cancer genes, FANCA, MAP3K1 and TP53 that associate with both anthropometric traits and cancer risk. Of particular interest, we identify a previously unrecognised strong association between the rs78378222[C] SNP in the 3' untranslated region (3'-UTR) of TP53 and both increased risk for developing non-melanomatous skin cancer (OR=1.36 (95% 1.31 to 1.41), adjusted p=7.62E
conclusionOur results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.
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