Evidence map›Paper›PMID 32591310›Full record

ArticleCardiovascular revascularization medicine : including molecular interventions2021

Machine-Learning-Based In-Hospital Mortality Prediction for Transcatheter Mitral Valve Repair in the United States.

Dagmar F Hernandez-Suarez, Sagar Ranka, Yeunjung Kim, Azeem Latib, Jose Wiley, Angel Lopez-Candales, Duane S Pinto, Maday C Gonzalez, Harish Ramakrishna, Cristina Sanina and 9 more

Abstract read
In one paragraph

Article in Cardiovascular revascularization medicine : including molecular interventions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Harnessing Artificial Intelligence for Innovation in Interventional Cardiovascular Care.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Review
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Comparing machine learning algorithms for predicting COVID-19 mortality.BMC medical informatics and decision making · 2022
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Dagmar F Hernandez-SuarezDivision of Cardiovascular Medicine, Department of Medicine, University of Puerto Rico School of Medicine, San Juan, PR, USA. Electronic address: dagmar.hernandez@upr.edu.
Sagar RankaDivision of Cardiovascular Medicine, Department of Medicine, University of Kansas School of Medicine, Kansas City, KS, USA.
Yeunjung KimDivision of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.
Azeem LatibDivision of Cardiology, Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, New York, NY, USA.
Jose WileyDivision of Cardiology, Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, New York, NY, USA.
Angel Lopez-CandalesDivision of Cardiology, Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Duane S PintoBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Maday C GonzalezDivision of Cardiology, Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, New York, NY, USA.
Harish RamakrishnaDivision of Cardiovascular and Thoracic Anesthesiology, Mayo Clinic, Rochester, MN, USA.
Cristina SaninaDivision of Cardiology, Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, New York, NY, USA.
Brenda G Nieves-RodriguezCenter for Collaborative Research in Health Disparities, University of Puerto Rico School of Medicine, San Juan, PR, USA.
Jovaniel Rodriguez-MaldonadoCenter for Collaborative Research in Health Disparities, University of Puerto Rico School of Medicine, San Juan, PR, USA.
Roberto Feliu MaldonadoCenter for Collaborative Research in Health Disparities, University of Puerto Rico School of Medicine, San Juan, PR, USA.
Israel J Rodriguez-RuizCenter for Collaborative Research in Health Disparities, University of Puerto Rico School of Medicine, San Juan, PR, USA.
Istoni da Luz Sant'AnaCenter for Collaborative Research in Health Disparities, University of Puerto Rico School of Medicine, San Juan, PR, USA.
Karlo A WileyCollege of Agriculture and Life Sciences, Cornell University, Ithaca, NY, USA.
Pedro Cox-AlomarDivision of Cardiology, Department of Medicine, Louisiana State University, New Orleans, LA, USA.
Pedro A VillablancaDivision of Cardiovascular Medicine, Department of Medicine, Henry Ford Hospital, Detroit, MI, USA.
Abiel Roche-LimaCenter for Collaborative Research in Health Disparities, University of Puerto Rico School of Medicine, San Juan, PR, USA.

Funding

SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Humberto Guillermo Ortiz-Zuazaga · 2012 to 2026
$52.9M
Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Emma Fernandez-Repollet · 2017 to 2026
$35.8M
Hispanics in Research Capability: SoHP & SOM Partnership (HIREC)S21MD001830 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI ELIAS BONETA, AUGUSTO R, ESTAPE, ESTELA S · 2005 to 2010
$30.0M
TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54MD007587 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LUCIANO, CARLOS A., WOJNA, VALERIE · 2012 to 2018
$23.2M
Tracking and Evaluation CoreU54GM133807 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI WOJNA, VALERIE · 2020 to 2024
$17.7M
Hispanic Clinical and Translational Research Education and Career Development ProgramR25MD007607 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Karen G. Martinez Gonzalez, Barbara Segarra-Vazquez · 2012 to 2026
$7.4M
Conduits: MSHS Translational Science HubTL1TR001434 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GABRILOVE, JANICE L · 2015 to 2019
$2.1M
NCATS NIH HHS TL1 TR001434NIGMS NIH HHS P20 GM103475NIGMS NIH HHS U54 GM133807NIMHD NIH HHS R25 MD007607NIMHD NIH HHS S21 MD001830NIMHD NIH HHS U54 MD007587NIMHD NIH HHS U54 MD007600
6 · The paper itself

Abstract

backgroundTranscatheter mitral valve repair (TMVR) utilization has increased significantly in the United States over the last years. Yet, a risk-prediction tool for adverse events has not been developed. We aimed to generate a machine-learning-based algorithm to predict in-hospital mortality after TMVR.

methodsPatients who underwent TMVR from 2012 through 2015 were identified using the National Inpatient Sample database. The study population was randomly divided into a training set (n = 636) and a testing set (n = 213). Prediction models for in-hospital mortality were obtained using five supervised machine-learning classifiers.

resultsA total of 849 TMVRs were analyzed in our study. The overall in-hospital mortality was 3.1%. A naïve Bayes (NB) model had the best discrimination for fifteen variables, with an area under the receiver-operating curve (AUC) of 0.83 (95% CI, 0.80-0.87), compared to 0.77 for logistic regression (95% CI, 0.58-0.95), 0.73 for an artificial neural network (95% CI, 0.55-0.91), and 0.67 for both a random forest and a support-vector machine (95% CI, 0.47-0.87). History of coronary artery disease, of chronic kidney disease, and smoking were the three most significant predictors of in-hospital mortality.

conclusionsWe developed a robust machine-learning-derived model to predict in-hospital mortality in patients undergoing TMVR. This model is promising for decision-making and deserves further clinical validation.

Indexed as

Mitral ValveMitral Valve InsufficiencyBayes TheoremHospital MortalityHumansMachine LearningUnited StatesMachine learningMortalityTranscatheter mitral valve repair

Identifiers

PMID32591310
PMCPMC7736498

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.