Evidence map›Paper›PMID 32591017›Full record

ArticleBMC infectious diseases2020

Global molecular diversity of RSV - the "INFORM RSV" study.

Annefleur C Langedijk, Robert Jan Lebbink, Christiana Naaktgeboren, Anouk Evers, Marco C Viveen, Anne Greenough, Terho Heikkinen, Renato T Stein, Peter Richmond, Federico Martinón-Torres and 19 more

Open access · goldAbstract readClinical StudyMulticenter Study
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

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  18. Transmission of paediatric respiratory syncytial virus and influenza in the wake of the COVID-19 pandemic.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 16 institutions in 12 countries.

Annefleur C LangedijkDepartment of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands.
Robert Jan LebbinkDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Christiana NaaktgeborenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Anouk EversDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Marco C ViveenDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Anne GreenoughDepartment of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Terho HeikkinenReSViNET foundation, Zeist, the Netherlands.
Renato T SteinCentro INFANT at Pontificia Universidade Catolica de Rio Grande do Sul, Porto Alegre, Brazil.
Peter RichmondDepartment of Paediatrics, The University of Queensland, Brisbane, Australia.
Federico Martinón-TorresDepartment of Paediatrics, Hospital Clínico Universitario de Santiago, Santiago, Galicia, Spain.
Marta NunesReSViNET foundation, Zeist, the Netherlands.
Mitsuaki HosoyaDepartment of Paediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
Christian KellerDepartment of Virology, University Hospital Giessen and Marburg, Marburg, Germany.
Monika BauckDepartment of Paediatrics, University Hospital Giessen and Marburg, Marburg, Germany.
Robert CohenAssociation Clinique et Thérapeutique Infantile du Val-de-Marne, CHI Créteil, GRC Gemini, Université Paris XII, Créteil, France.
Jesse PapenburgDepartment of Paediatrics, Division of Pediatric Infectious Diseases, Montreal Children's Hospital, McGill University Health Centre, Montreal, Canada.
Jeffrey PernicaDepartment of Paediatrics, McMaster University, Hamilton, Canada.
Marije P HennusPaediatric Intensive Care Unit, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands.
Hong JinAstraZeneca, Gaithersburg/South San Francisco, USA.
David E TaborAstraZeneca, Gaithersburg/South San Francisco, USA.
Andrev TovchigrechkoAstraZeneca, Gaithersburg/South San Francisco, USA.
Alexey RuzinAstraZeneca, Gaithersburg/South San Francisco, USA.
Michael E AbramAstraZeneca, Gaithersburg/South San Francisco, USA.
Deidre WilkinsAstraZeneca, Gaithersburg/South San Francisco, USA.
Joanne G WildenbeestDepartment of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands.
Leyla Kragten-TabatabaieReSViNET foundation, Zeist, the Netherlands.
Frank E J CoenjaertsDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Mark T EsserAstraZeneca, Gaithersburg/South San Francisco, USA.
Louis J BontDepartment of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands. l.bont@umcutrecht.nl.
AstraZeneca (United States) · USUniversity Medical Center Utrecht · NLUniversitätsklinikum Gießen und Marburg · DEWilhelmina Children's Hospital · NLAssociation Clinique et Thérapeutique Infantile du Val de Marne · FRComplejo Hospitalario Universitario de Santiago · ESFukushima Medical University · JPKing's College London · GBMcGill University Health Centre · CAMcMaster University · CANational Research Foundation · ZAPontifícia Universidade Católica do Rio Grande do Sul · BRUniversity of Queensland · AUUniversity of Turku · FIUtrecht University · NLYulius · NL

Funding

AstraZeneca NA
6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ReSViNET to investigate the worldwide molecular diversity of RSV isolates collected from children less than 5 years of age.

methodsThe INFORM study is performed in 17 countries spanning all inhabited continents and will provide insight into the molecular epidemiology of circulating RSV strains worldwide. Sequencing of > 4000 RSV-positive respiratory samples is planned to detect temporal and geographical molecular patterns on a molecular level over five consecutive years. Additionally, RSV will be cultured from a subset of samples to study the functional implications of specific mutations in the viral genome including viral fitness and susceptibility to different monoclonal antibodies. DISCUSSION: The sequencing and functional results will be used to investigate susceptibility and resistance to novel RSV preventive or therapeutic interventions. Finally, a repository of globally collected RSV strains and a database of RSV sequences will be created.

Indexed as

Genome, ViralPolymorphism, GeneticAntibodies, MonoclonalAntiviral AgentsChild, PreschoolDrug Resistance, BacterialFemaleGenotypeHumansImmunization, PassiveInfantInfant, NewbornMaleMolecular EpidemiologyProspective StudiesRespiratory Syncytial Virus, HumanAntibodies, MonoclonalAntiviral AgentsMolecular epidemiologyMonoclonal antibodiesNext generation sequencingRespiratory syncytial virusTemporal and geographical diversityVaccines

Identifiers

PMID32591017
PMCPMC7316634
OpenAlexW3037717704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.