ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Impact of ADCYAP1R1 genotype on longitudinal fear conditioning in children: interaction with trauma and sex.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Pooled it
- The progesterone to estradiol ratio predicts fear extinction in mice and humans.Neurobiology of stress · 2026Article
- The functional heterogeneity of PACAP: Stress, learning, and pathology.Neurobiology of learning and memory · 2023Review
- Does age matter in genetics? The role of ADCYAP1R1 in sex-specific risk for posttraumatic stress disorder in trauma-exposed preadolescent children.Journal of psychiatric research · 2023Article
- Genome-wide association study identified six loci associated with adverse drug reactions to aripiprazole in schizophrenia patients.Schizophrenia (Heidelberg, Germany) · 2023Article
- Pre-Learning Stress That Is Temporally Removed from Acquisition Impairs Fear Learning.Biology · 2023Article
- PACAP-expressing neurons in the lateral habenula diminish negative emotional valence.Genes, brain, and behavior · 2022Article
- PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus.Nature communications · 2022Article
- The pituitary adenylate cyclase-activating polypeptide system as a sex-specific modulator of hippocampal response to threat stimuli.Neurobiology of stress · 2022Article
- Safety learning during development: Implications for development of psychopathology.Behavioural brain research · 2021Review
- Genomic factors underlying sex differences in trauma-related disorders.Neurobiology of stress · 2021Article
- A legacy of fear: Physiological evidence for intergenerational effects of trauma exposure on fear and safety signal learning among African Americans.Behavioural brain research · 2021Article
- Pituitary Adenylate Cyclase-Activating Polypeptide in Learning and Memory.Frontiers in cellular neuroscience · 2021Review
- TheFrontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Dysregulated fear conditioned responses have been associated with PTSD in adults, with increased fear-potentiated startle (FPS) serving as a potential intermediate phenotype for PTSD risk. This phenotype has also been associated with stress-related ADCYAP1R1 gene variants in adult women. However, FPS and genotype have not yet been examined during development. The aim of this study was to examine developmental changes in fear conditioning, and to see whether these changes were impacted by genotype and trauma. Differential fear conditioning using FPS was tested in n = 63 children ages 8-13 at two visits (V1, V2) 1 year apart. Startle response was measured using electromyograph recordings of the eyeblink muscle. The rs2267735 SNP of the ADCYAP1R1 gene was extracted from genome-wide (GWAS) analyses. Trauma exposure was assessed using the Violence Exposure Scale-Revised (VEX-R). We found significant Visit by Genotype interactions, with CC genotype increasing FPS from V1 to V2. At V2 there was a Genotype by Violence interaction, with higher FPS in the CC vs G allele groups among those with higher violence exposure (F = 17.46, p = 0.0002). Females with the CC genotype had higher FPS compared to G allele females (F = 12.09, p = 0.002); there were no effects of genotype in males. This study showed Gene × Environment × Development and Gene × Sex effects of ADCYAP1R1 in a high-risk pediatric population. Those with the CC genotype and high levels of violence exposure, as well as females with the CC genotype, showed the greatest conditioned fear responses in adolescence.
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Registered trials
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