ArticleMedicine2020
Perinatal risk factors for congenital hypothyroidism: A retrospective cohort study performed at a tertiary hospital in China.
Article in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Association of pregnancy outcomes with neonatal TSH levels in euthyroid singleton pregnancies.Frontiers in endocrinology · 2025Observational
- [Investigation of influencing factors and reference ranges for thyroid function in hospitalized preterm infants at the age of 7 days].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Epidemiological profile of congenital hypothyroidism at a southern Brazilian state.Archives of endocrinology and metabolism · 2023Article
- Analysis of Risk Factors and Screening Results of Neonatal Congenital Hypothyroidism in a Tertiary Care Center of Southern China.Journal of multidisciplinary healthcare · 2023Article
- Birthweight and subsequent risk for thyroid and autoimmune conditions in postmenopausal women.Journal of developmental origins of health and disease · 2022Article
- Review
- Utility of Repeat Testing for Congenital Hypothyroidism in Infants with Very Low Birth Weight.The Journal of pediatrics · 2022Article
- Primary Congenital Hypothyroidism in Children Below 3 Years Old - Etiology and Treatment With Overtreatment and Undertreatment Risks, a 5-Year Single Centre Experience.Frontiers in endocrinology · 2022Article
- Congenital Hypothyroidism in Preterm Newborns - The Challenges of Diagnostics and Treatment: A Review.Frontiers in endocrinology · 2022Review
- Maternal exposure to OEnvironmental science and pollution research international · 2021Article
- Prevalence and predictive factors of transient and permanent congenital hypothyroidism in Fars province, Iran.BMC pediatrics · 2021Article
- Congenital hypothyroidism in Indian preterm babies - screening, prevalence, and aetiology.Pediatric endocrinology, diabetes, and metabolism · 2021Observational
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital hypothyroidism (CH) is one of the most common neonatal endocrine diseases. This retrospective cohort study aimed to identify the potential perinatal risk factors for CH and to differentiate between transient and permanent CH (TCH and PCH, respectively) as well as determine their prevalence in a southeastern Chinese population.This study was based on an 18-year surveillance of a neonatal CH screening program in a large tertiary hospital. A retrospective review of the maternal and neonatal perinatal exposures was conducted.Of the 205,834 newborns screened between 2000 and 2018, 189 were diagnosed with CH (1/1089). Among the 131 CH patients who again underwent thyroid function testing (TFT) after discontinuation of levothyroxine at the age of 3 years, 61 (46.6%) were diagnosed with PCH and 70 (53.4%) were diagnosed with TCH. In the maternal characteristics model, women aged 35 years or older and those who had thyroid disease and/or diabetes mellitus during pregnancy had increased risk of having an offspring with CH (P = .001, .000, and .001, respectively). Significant associations were found with regard to parity and the risk of CH in the offspring (P = .000). In the neonatal characteristics model, infants with female sex, preterm birth, post-term birth, low birth weight, other birth defects, and those born as part of multiple births (P = .011, .034, .001, .000, .000, and .003, respectively) had increased risk of CH. The rate of newborns with other birth defects was higher in the PCH group than that in the TCH group (P = .008), whereas the rate of maternal thyroid disease, newborns with low birth weight, and newborns with preterm birth was higher in the TCH group than that in the PCH group (P = .041, .020, and .013, respectively). The levothyroxine dose (μg/kg/day) at 1 year, 2 years, and 3 years old was significantly lower in the TCH group than that in the PCH group (P = .000, .000, and .000, respectively).Perinatal factors should be considered during the diagnosis and treatment of CH.
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