Evidence map›Paper›PMID 32590406›Full record

Trial reportJournal of clinical psychopharmacology

Opioid Receptor μ-1 and Ketamine Effects in a Suicidal Depression Trial: A Post Hoc Exploration.

Michael F Grunebaum, Hanga C Galfalvy, Jun Liu, Yung-Yu Huang, Stephen Marcott, Ainsley K Burke, J John Mann

Abstract readLetterRandomized Controlled Trial
In one paragraph

Trial report in Journal of clinical psychopharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Is the antidepressant efficacy of ketamine and esketamine mediated via opioid mechanisms?European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Genetics of Response to ECT, TMS, Ketamine and Esketamine.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael F Grunebaum
Hanga C Galfalvy
Jun Liu
Yung-Yu Huang
Stephen Marcott
Ainsley K Burke
J John Mann

Funding

Ketamine vs Midazolam: Testing Rapid Relief of Suicide Risk in DepressionR01MH096784 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI GRUNEBAUM, MICHAEL F · 2012 to 2016
$2.8M
NIMH NIH HHS R01 MH096784
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Suicidal IdeationAdministration, IntravenousGenotypeHumansKetamineMajor Depressive DisorderMidazolamPolymorphism, Single NucleotideReceptors, Opioid, muKetamineMidazolamOPRM1 protein, humanReceptors, Opioid, mu

Identifiers

PMID32590406
PMCPMC7347432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.