Evidence map›Paper›PMID 32590333›Full record

ArticleNeuroImage. Clinical2020

Dynamic association between AT(N) profile and cognition mediated by cortical thickness in Alzheimer's continuum.

Jae-Won Jang, Yeshin Kim, Seongheon Kim, Sang Won Park, Sung Ok Kwon, Young Ho Park, Jae-Sung Lim, Young Chul Youn, Sung Hun Kim, SangYun Kim and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Jae-Won JangDepartment of Neurology, Kangwon National University Hospital, Chuncheon, Republic of Korea; Kangwon National University School of Medicine, Chuncheon, Republic of Korea. Electronic address: light26@kangwon.ac.kr.
Yeshin KimDepartment of Neurology, Kangwon National University Hospital, Chuncheon, Republic of Korea; Kangwon National University School of Medicine, Chuncheon, Republic of Korea. Electronic address: yeshins@gmail.com.
Seongheon KimDepartment of Neurology, Kangwon National University Hospital, Chuncheon, Republic of Korea; Kangwon National University School of Medicine, Chuncheon, Republic of Korea. Electronic address: dr.kim94@gmail.com.
Sang Won ParkKangwon National University School of Medicine, Chuncheon, Republic of Korea. Electronic address: chicwon229@kangwon.ac.kr.
Sung Ok KwonBiomedical Research Institute, Kangwon National University Hospital, Chuncheon, Republic of Korea. Electronic address: kamelon@hanmail.net.
Young Ho ParkDepartment of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea; Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: kumimesy@snubh.org.
Jae-Sung LimDepartment of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea. Electronic address: rophe.pneuma@gmail.com.
Young Chul YounDepartment of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea. Electronic address: neudoc@cau.ac.kr.
Sung Hun KimDepartment of Neurology, Kangwon National University Hospital, Chuncheon, Republic of Korea; Kangwon National University School of Medicine, Chuncheon, Republic of Korea. Electronic address: marinen@kangwon.ac.kr.
SangYun KimDepartment of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea; Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: neuroksy@snu.ac.kr.
Alzheimer's Disease Neuroimaging Initiative
Kangwon National University · KRSeoul National University · KRHallym University · KRSeoul National University Bundang Hospital · KR

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

backgroundThe recently-proposed National Institute on Aging and Alzheimer's Association research framework organizes Alzheimer's disease (AD) biomarkers based on amyloid/tau/neurodegeneration (AT(N)). This study investigated the mediating effect of structural change in brain MRI on changes in cognitive function according to initial AT(N) profiles.

methodsWe included 576 subjects (cognitively unimpaired (N = 136), mild cognitive impairment (N = 294), dementia (N = 146)) from the Alzheimer's disease Neuroimaging Initiative study. The parallel-process latent growth curve model was applied to test the mediational effect of cortical thickness growth trajectory between the initial AT(N) profiles and cognitive growth trajectory.

resultsIn Alzheimer's continuum, only the A + T + (N)+ profile showed a mediational effect of the cortical thickness growth trajectory. A + T - (N)- was not sufficient to induce direct or indirect effects on cognitive dysfunction, and A + T + (N)- showed a significant direct path from an altered cortical thickness to cognitive decline.

conclusionThe sequential effect between changes in brain MRI and cognition varied by baseline AT(N) profile, suggesting the dynamic changes in the relationships among biomarkers in the current cascade model.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersBrainCognitionCognitive DysfunctionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingAmyloid beta-PeptidesBiomarkersAlzheimer’s diseaseBeta amyloidBrain MRICSF biomarkersMild cognitive impairmentParallel process latent growth curve modelStructural equation modelingTau

Identifiers

PMID32590333
PMCPMC7322096
OpenAlexW3029155578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.