ArticleRedox biology2020
Differential endothelial signaling responses elicited by chemogenetic H
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In one paragraph
Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Hydrogen peroxide sensing and signaling in physiology and disease: implications for therapy.Signal transduction and targeted therapy · 2026Review
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- Osteoblast dysfunction associated with mitophagy suppression under simulated microgravity.Biomedical engineering online · 2025Article
- Prolonged In Vivo Chemogenetic Generation of Hydrogen Peroxide by Endothelial Cells Induces Cardiac Remodelling and Vascular Dysfunction.Antioxidants (Basel, Switzerland) · 2025Article
- Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging.Nature aging · 2025Article
- Advancing Neuroscience and Therapy: Insights into Genetic and Non-Genetic Neuromodulation Approaches.Cells · 2025Review
- Subcellular Localization Guides eNOS Function.International journal of molecular sciences · 2024Review
- AQP1 differentially orchestrates endothelial cell senescence.Redox biology · 2024Article
- FRBM Mini REVIEW: Chemogenetic approaches to probe redox dysregulation in heart failure.Free radical biology & medicine · 2024Review
- D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress.Current opinion in chemical biology · 2024Review
- FOXO transcription factors as mediators of stress adaptation.Nature reviews. Molecular cell biology · 2024Review
- Targeting the redox system for cardiovascular regeneration in aging.Aging cell · 2023Review
- Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.Immunity · 2023Article
- Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury.Cell death & disease · 2023Article
- Factors and Pathways Modulating Endothelial Cell Senescence in Vascular Aging.International journal of molecular sciences · 2022Review
- Reactive Oxygen Species Differentially Modulate the Metabolic and Transcriptomic Response of Endothelial Cells.Antioxidants (Basel, Switzerland) · 2022Article
- Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology.Annual review of pharmacology and toxicology · 2022Article
- Complexities of the chemogenetic toolkit: Differential mDAAO activation by d-amino substrates and subcellular targeting.Free radical biology & medicine · 2021Article
- Dissecting in vivo and in vitro redox responses using chemogenetics.Free radical biology & medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Seyed Soheil Saeedi SaraviDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Emrah ErogluDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Markus Waldeck-WeiermairDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010, Graz, Austria.
Andrea SorrentinoDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Benjamin SteinhornDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Vselovod BelousovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
Thomas MichelDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA. Electronic address: thomas_michel@hms.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USInstitute of Bioorganic Chemistry · RU
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MTransgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4MChemogenetic Neurovascular Oxidative Stress: Neurodegeneration and Cardiac RemodelingR01NS131182 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Thomas Michel · 2024 to 2026
$2.3MHydrogen peroxide in endothelial function and dysfunctionR01HL152173 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHEL, THOMAS · 2021 to 2024
$2.2MDynamic tissue-specific modulation of redox stress using chemogeneticsR33HL157918 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHEL, THOMAS · 2021 to 2022
$1.0MChemogenetic approaches to define the roles of redox dysfunction in the cardiomyopathy of agingR21AG063073 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHEL, THOMAS · 2019 to 2020
$480kAustrian Science Fund FWF J 4113NHLBI NIH HHS R01 HL152173NHLBI NIH HHS R33 HL157918NIA NIH HHS R21 AG063073NIDDK NIH HHS P30 DK057521NIGMS NIH HHS T32 GM007753NINDS NIH HHS R01 NS131182
Abstract
Hydrogen peroxide (H
Indexed as
Endothelial CellsHydrogen PeroxideAMP-Activated Protein KinasesHumansNitric OxideNitric Oxide Synthase Type IIIPhosphorylationSignal TransductionAMP-Activated Protein KinasesHydrogen PeroxideNitric OxideNitric Oxide Synthase Type IIIBiosensorsChemogeneticseNOSHydrogen peroxidePhosphorylationSignal transductionSubcellular targeting
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.