ReviewCell2020
Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.
Review in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 202 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identifying Markers of Exercise Training in Heart Failure
Optimizing Muscle and Bone Mechanoadaptation to Physical Training: Mechanistic Control Paths Via Muscle and Bone Crosstalk to Altered Mechanical Loading
Who cites it
202 citing papers in PubMed, 7 syntheses or guidelines pooled it, 278 citations in OpenAlex.
- Physical activity, sedentary behavior and microbiome: A systematic review and meta-analysis.Journal of science and medicine in sport · 2024Pooled it
- Sex differences in muscle protein expression and DNA methylation in response to exercise training.Biology of sex differences · 2023Pooled it
- The Metabolic Signature of Cardiorespiratory Fitness: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Transcriptional and Epigenetic Response to Sedentary Behavior and Physical Activity in Children and Adolescents: A Systematic Review.Frontiers in pediatrics · 2022Pooled it
- The Importance of Lipidomic Approach for Mapping and Exploring the Molecular Networks Underlying Physical Exercise: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Time trajectories in the transcriptomic response to exercise - a meta-analysis.Nature communications · 2021Pooled it
- The metabolic signature of cardiorespiratory fitness: a protocol for a systematic review and meta-analysis.BMJ open sport & exercise medicine · 2021Pooled it
- NSAIDs trigger drug-specific response to exercise: a multi-omics systems biology analysis of a randomized crossover trial.Skeletal muscle · 2026Trial
- Exercise intensity determines circulating levels of Lac-Phe and other exerkines: a randomized crossover trial.Metabolomics : Official journal of the Metabolomic Society · 2025Trial
- Trial
- Dynamic transcriptomic responses to divergent acute exercise stimuli in young adults.Physiological genomics · 2023Trial
- No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial.Nature communications · 2022Trial
- Muscle transcriptional networks linked to resistance exercise training hypertrophic response heterogeneity.Physiological genomics · 2021Trial
- Precision Exercise for Breast Cancer-Related Outcomes: Towards Personalised Training Based on Tumour, Treatment and Patient Characteristics.Sports medicine (Auckland, N.Z.) · 2026Review
- A multi-fluid exercise proteomic atlas reveals regulators of health and disease.Nature metabolism · 2026Article
- Exerkines in precision management of metabolic diseases.Chinese medical journal · 2026Review
- Integrative plasma proteomic network analysis identifies physical activity-associated protein modules potentially mediating type 2 diabetes risk.Cardiovascular diabetology · 2026Article
- Review
- Long-distance trail running induces functional iron deficiency driven by inflammation.Blood advances · 2026Article
- Serum metabolomics signatures after an acute bout of combined traditional or high-intensity tactical training in young adults.Physiological reports · 2026Article
142 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 10 institutions in 1 country.
Funding
Abstract
Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.