ArticleCell metabolism2020
Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation.
Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Relationship between aerobic fitness and adipose tissue insulin resistance.American journal of physiology. Endocrinology and metabolism · 2026Pooled it
- Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution.Nature metabolism · 2025Guideline
- Trial
- Systems genetics reveals ITIH5 as a key mediator of adipocyte-Endothelial crosstalk.Molecular metabolism · 2026Article
- The nature of sex differences in catecholamine-induced lipolysis in subcutaneous fat cells.iScience · 2025Article
- Role of Neuronal Cholecystokinin Receptor: An Emerging Therapeutic Target for Ameliorating Neurological Diseases.Molecular neurobiology · 2025Review
- A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium.Life medicine · 2025Article
- Adipose tissue ageing: implications for metabolic health and lifespan.Nature reviews. Endocrinology · 2025Review
- Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice.Nature communications · 2024Article
- Cancer cachexia: biomarkers and the influence of age.Molecular oncology · 2024Review
- Mitochondria, Autophagy and Inflammation: Interconnected in Aging.Cell biochemistry and biophysics · 2024Review
- A spatiotemporal proteomic map of human adipogenesis.Nature metabolism · 2024Article
- Monoamine oxidase mediated oxidative stress: a potential molecular and biochemical crux in the pathogenesis of obesity.Molecular biology reports · 2023Review
- From the Sun to the Cell: Examining Obesity through the Lens of Vitamin D and Inflammation.Metabolites · 2023Review
- Increased OCT3 Expression in Adipose Tissue With Aging: Implications for Catecholamine and Lipid Turnover and Insulin Resistance in Women.Endocrinology · 2023Article
- Adipose METTL14-Elicited NAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- The Transcriptomic Landscape of Age-Induced Changes in Human Visceral Fat and the Predicted Omentum-Liver Connectome in Males.Biomedicines · 2023Article
- Characteristic and fate determination of adipose precursors during adipose tissue remodeling.Cell regeneration (London, England) · 2023Review
- Macrophage function in adipose tissue homeostasis and metabolic inflammation.Nature immunology · 2023Review
- Brown Adipose Tissue-A Translational Perspective.Endocrine reviews · 2023Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gao et al. report that the observed reduction in adipose lipolysis with age in women could be explained by an upregulation of the catecholamine-degradation pathway in subcutaneous adipocytes. However, in contrast to findings in mice, these pathways are enriched in adipocytes and not in immune cells, suggesting species-specific differences in aging mechanisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.