Evidence map›Paper›PMID 32589921›Full record

ReviewBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2020

Summary of the 2019 Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling.

Sarah A Holstein, Alan Howard, David Avigan, Manisha Bhutani, Adam D Cohen, Luciano J Costa, Madhav V Dhodapkar, Francesca Gay, Nicole Gormley, Damian J Green and 17 more

Abstract readReview
In one paragraph

Review in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Sarah A HolsteinUniversity of Nebraska Medical Center, Omaha, Nebraska. Electronic address: sarah.holstein@unmc.edu.
Alan HowardCenter for International Blood and Marrow Transplant Research, Minneapolis, Minnesota.
David AviganBeth Israel Deaconess Medical Center, Boston, Massachusetts.
Manisha BhutaniLevine Cancer Institute, Charlotte, North Carolina.
Adam D CohenAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
Luciano J CostaUniversity of Alabama at Birmingham, Birmingham, Alabama.
Madhav V DhodapkarWinship Cancer Institute of Emory University, Atlanta, Georgia.
Francesca GayMyeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.
Nicole GormleyUS Food and Drug Administration, Silver Spring, Maryland.
Damian J GreenFred Hutchinson Cancer Research Center & Seattle Cancer Care Alliance, Seattle, Washington.
Jens HillengassRoswell Park Comprehensive Cancer Center, Buffalo, New York.
Neha KordeMemorial Sloan Kettering Cancer Center, New York, New York.
Zihai LiThe Ohio State University, Columbus, Ohio.
Sham MailankodyMemorial Sloan Kettering Cancer Center, New York, New York.
Paola NeriUniversity of Calgary, Calgary, Alberta.
Samir ParekhIcahn School of Medicine at Mount Sinai, New York, New York.
Marcelo C PasquiniMedical College of Wisconsin, Milwaukee, Wisconsin.
Noemi PuigInstitute for Biomedical Research of Salamanca, University Hospital of Salamanca, Salamanca, Spain.
G David RoodmanIndiana University School of Medicine, Indianapolis, Indiana.
Mehmet Kemal SamurDana-Farber Cancer Institute, Boston, Massachusetts.
Nina ShahUniversity of California San Francisco, San Francisco, California.
Urvi A ShahMemorial Sloan Kettering Cancer Center, New York, New York.
Qian ShiMayo Clinic, Rochester, Minnesota.
Andrew SpencerAlfred Hospital-Monash University, Melbourne, Victoria.
Vera J SumanMayo Clinic, Rochester, Minnesota.
Saad Z UsmaniLevine Cancer Institute, Charlotte, North Carolina.
Philip L McCarthyRoswell Park Comprehensive Cancer Center, Buffalo, New York.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Blood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc.U24HL138660 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Steven M. DeVine, Mehdi Hussain Hamadani · 2017 to 2026
$71.4M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
Glucocorticoid-induced Atrophy in Bone and MuscleR01AR059357 · NIAMS · UNIV OF ARKANSAS FOR MED SCIS · PI BELLIDO, TERESITA M. · 2011 to 2022
$3.4M
MSKCC BMT CTN RenewalUG1HL069315 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI MIGUEL-ANGEL PERALES · 2017 to 2026
$2.2M
Mount Sinai Core Clinical Consortium for the BMT Clinical Trials NetworkUG1HL138645 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JOHN LEVINE · 2017 to 2026
$1.9M
Manipulating the N-end Rule Protein Degradation Pathway to Build Bone and Decrease Tumor Growth in Multiple Myeloma Bone DiseaseR01CA241677 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI CHIRGWIN, JOHN M · 2020 to 2024
$1.6M
BLRD VA IK6 BX004596NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA241677NCI NIH HHS U24 CA076518NHLBI NIH HHS U10 HL069294NHLBI NIH HHS U24 HL138660NHLBI NIH HHS UG1 HL069315NHLBI NIH HHS UG1 HL138645NIAMS NIH HHS R01 AR059357
6 · The paper itself

Abstract

The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Myeloma Intergroup has organized an annual workshop focused on minimal residual disease (MRD) testing and immune profiling (IP) in multiple myeloma since 2016. In 2019, the workshop took place as an American Society of Hematology (ASH) Friday Scientific Workshop titled "Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma." This workshop focused on 4 main topics: the molecular and immunologic evolution of plasma cell disorders, development of new laboratory- and imaging-based MRD assessment approaches, chimeric antigen receptor T cell therapy research, and statistical and regulatory issues associated with novel clinical endpoints. In this report, we provide a summary of the workshop and discuss future directions.

Indexed as

Multiple MyelomaBone MarrowHumansNeoplasm, ResidualCAR T cellEndpointImmune profilingMinimal residual diseaseMultiple myeloma

Identifiers

PMID32589921
PMCPMC7529908

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.